PDB entry 6wmw

View 6wmw on RCSB PDB site
Description: GFRAL receptor bound with two antibody Fabs (3P10, 25M22)
Class: immune system
Keywords: receptor, signaling, antibodes, immune system
Deposited on 2020-04-21, released 2020-07-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-27, with a file datestamp of 2021-01-22.
Experiment type: XRAY
Resolution: 2.91 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: GDNF family receptor alpha-like
    Species: Homo sapiens [TaxId:9606]
    Gene: GFRAL, C6orf144, UNQ9356/PRO34128
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: FAB3P10 heavy chain fragment
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WMW
  • Chain 'L':
    Compound: FAB3P10 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WMW (0-217)
    Domains in SCOPe 2.08: d6wmwl1, d6wmwl2
  • Chain 'M':
    Compound: FAB25M22 heavy chain fragment
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WMW (0-End)
    Domains in SCOPe 2.08: d6wmwm1, d6wmwm2
  • Chain 'N':
    Compound: FAB25M22 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WMW
    Domains in SCOPe 2.08: d6wmwn1, d6wmwn2

PDB Chain Sequences:

  • Chain 'B':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6wmwL (L:)
divltqspvslavslgqratiscrasesvdnygisfmswfqqkpgqppklliyaashqgs
gvparfsgsgsgtdfslnihpmeeddsamyfclqskevpwtfgggtkleikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >6wmwM (M:)
qvqlqqsgpdlvkpgasvkisckasgytftsywvnwmkqrpgkglewigriypgdgdtny
ngkfkgkatltadkssstaymqlssltsedsavyfcarayllrlrrtgyyamdywgqgts
vtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdevd

    Sequence, based on observed residues (ATOM records): (download) 
    >6wmwM (M:)
qvqlqqsgpdlvkpgasvkisckasgytftsywvnwmkqrpgkglewigriypgdgdtny
ngkfkgkatltadkssstaymqlssltsedsavyfcarayllrlrrtgyyamdywgqgts
vtvssastkgpsvfplapstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >6wmwN (N:)
mdmrvpaqllgllllwlrgarcdvvltqtplslpvnigdqasisckstksllnsdeftyl
dwylqkpgqspqlliflvsnrfsgvpdrfsgsgsgtdftlkisrveaedlgvyycfqsny
lpytfgggtkleikrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdna
lqsgnsqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrge
c

    Sequence, based on observed residues (ATOM records): (download) 
    >6wmwN (N:)
dvvltqtplslpvnigdqasisckstksllnsdeftyldwylqkpgqspqlliflvsnrf
sgvpdrfsgsgsgtdftlkisrveaedlgvyycfqsnylpytfgggtkleikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnr