PDB entry 6vrn

View 6vrn on RCSB PDB site
Description: T cell receptor-p53-HLA-A2 complex
Class: immune system
Keywords: TCR complex, MHC, HLA, adoptive cell therapy, IMMUNE SYSTEM
Deposited on 2020-02-08, released 2020-06-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-06-24, with a file datestamp of 2020-06-19.
Experiment type: XRAY
Resolution: 2.46 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MHC class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vrna1, d6vrna2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d6vrnb1, d6vrnb2
  • Chain 'D':
    Compound: T-cell receptor 38-10, alfa chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6VRN
    Domains in SCOPe 2.08: d6vrnd1, d6vrnd2
  • Chain 'E':
    Compound: TCR repeptor 38-10, beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6VRN
    Domains in SCOPe 2.08: d6vrne1, d6vrne2
  • Chain 'P':
    Compound: Cellular tumor antigen p53 peptide
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53, P53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637 (0-8)
      • engineered mutation (7)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vrnA (A:)
mgshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpey
wdgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyayd
gkdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketl
qrtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdg
tfqkwaavvvpsgqeqrytchvqheglpkpltlrweggglndifeaqkiewhe

    Sequence, based on observed residues (ATOM records): (download) 
    >6vrnA (A:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrw

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6vrnB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6vrnD (D:)
maqtvtqsqpemsvqeaetvtlsctydtsennyylfwykqppsrqmilvirqeaykqqna
tenrfsvnfqkaaksfslkisdsqlgdtamyfcafmgysgagsyqltfgkgtklsvipni
qnpdpavyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsa
vawsnksdfacanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >6vrnD (D:)
qtvtqsqpemsvqeaetvtlsctydtsennyylfwykqppsrqmilvirqeayknrfsvn
fqkaaksfslkisdsqlgdtamyfcafmgysgagsyqltfgkgtklsvipniqnpdpavy
qlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksd
facanafn

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6vrnE (E:)
mdagitqsprhkvtetgtpvtlrchqtenhrymywyrqdpghglrlihysygvkdtdkge
vsdgysvsrsktedflltlesatssqtsvyfcaiselvtgdsplhfgngtrltvtedlkn
vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
qpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
wgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >6vrnE (E:)
agitqsprhkvtetgtpvtlrchqtenhrymywyrqdpghglrlihysygvkdtdkgevs
dgysvsrsktedflltlesatssqtsvyfcaiselvtgdsplhfgngtrltvtedlknvf
ppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqp
alndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawg
ra

  • Chain 'P':
    No sequence available.