PDB entry 6vrm

View 6vrm on RCSB PDB site
Description: T cell receptor-p53-HLA-A2 complex
Class: immune system
Keywords: TCR complex, MHC, HLA, adoptive cell therapy, IMMUNE SYSTEM
Deposited on 2020-02-08, released 2020-06-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-06-24, with a file datestamp of 2020-06-19.
Experiment type: XRAY
Resolution: 2.61 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MHC class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vrma1, d6vrma2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d6vrmb1, d6vrmb2
  • Chain 'D':
    Compound: T-cell receptor 12-6, alfa chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6VRM
    Domains in SCOPe 2.08: d6vrmd1, d6vrmd2
  • Chain 'E':
    Compound: TCR 12-6, beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6VRM (Start-245)
    Domains in SCOPe 2.08: d6vrme1, d6vrme2
  • Chain 'P':
    Compound: Cellular tumor antigen p53 peptide
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53, P53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637 (0-8)
      • engineered mutation (7)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vrmA (A:)
mgshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpey
wdgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyayd
gkdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketl
qrtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdg
tfqkwaavvvpsgqeqrytchvqheglpkpltlrweggglndifeaqkiewhe

    Sequence, based on observed residues (ATOM records): (download) 
    >6vrmA (A:)
shsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeywd
getrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydgk
dyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlqr
tdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgtf
qkwaavvvpsgqeqrytchvqheglpkpltlrw

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6vrmB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6vrmD (D:)
mrkeveqdpgpfnvpegatvafnctysnsasqsffwyrqdcrkepkllmsvyssgnedgr
ftaqlnrasqyisllirdsklsdsatylcvvqpggyqkvtfgtgtklqvipniqnpdpav
yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnks
dfacanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >6vrmD (D:)
keveqdpgpfnvpegatvafnctysnsasqsffwyrqdcrkepkllmsvyssgnedgrft
aqlnrasqyisllirdsklsdsatylcvvqpggyqkvtfgtgtklqvipniqnpdpavyq
rdvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnafnnsiipedtf
fps

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6vrmE (E:)
mnagvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkge
vpngynvsrlnkrefslrlesaapsqtsvyfcasseglwqvgdeqyfgpgtrltvtedlk
nvfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplk
eqpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsae
awgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >6vrmE (E:)
agvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkgevp
ngynvsrlnkrefslrlesaapsqtsvyfcasseglwqvgdeqyfgpgtrltvtedlknv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeq
palndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
grad

  • Chain 'P':
    No sequence available.