PDB entry 6uht

View 6uht on RCSB PDB site
Description: Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-G10
Class: toxin/antitoxin
Keywords: Botulinum neurotoxin (BoNT), VHH, receptor-binding domain, TOXIN, ANTITOXIN, TOXIN-ANTITOXIN complex
Deposited on 2019-09-28, released 2020-03-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-03-04, with a file datestamp of 2020-02-28.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: botulinum neurotoxin type b
    Species: Clostridium botulinum [TaxId:1491]
    Gene: botB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10844 (5-437)
      • expression tag (2-4)
    Domains in SCOPe 2.07: d6uhta1, d6uhta2, d6uhta3
  • Chain 'B':
    Compound: botulinum neurotoxin type b
    Species: Clostridium botulinum [TaxId:1491]
    Gene: botB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6uhtb1, d6uhtb2
  • Chain 'C':
    Compound: jli-g10
    Species: Vicugna pacos [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 6UHT
    Domains in SCOPe 2.07: d6uhtc_
  • Chain 'D':
    Compound: jli-g10
    Species: Vicugna pacos [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 6UHT
    Domains in SCOPe 2.07: d6uhtd1, d6uhtd2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6uhtA (A:)
gplgseilnniilnlrykdnnlidlsgygakvevydgvelndknqfkltssanskirvtq
nqniifnsvfldfsvsfwiripkykndgiqnyihneytiincmknnsgwkisirgnriiw
tlidingktksvffeynirediseyinrwffvtitnnlnnakiyingklesntdikdire
viangeiifkldgdidrtqfiwmkyfsifntelsqsnieerykiqsyseylkdfwgnplm
ynkeyymfnagnknsyiklkkdspvgeiltrskynqnskyinyrdlyigekfiirrksns
qsinddivrkedyiyldffnlnqewrvytykyfkkeeeklflapisdsdefyntiqikey
deqptyscqllfkkdeestdeigligihrfyesgivfeeykdyfciskwylkevkrkpyn
lklgcnwqfipkdegwte

    Sequence, based on observed residues (ATOM records): (download) 
    >6uhtA (A:)
lgseilnniilnlrykdnnlidlsgygakvevydgvelndknqfkltssanskirvtqnq
niifnsvfldfsvsfwiripkykndgiqnyihneytiincmknnsgwkisirgnriiwtl
idingktksvffeynirediseyinrwffvtitnnlnnakiyingklesntdikdirevi
angeiifkldgdidrtqfiwmkyfsifntelsqsnieerykiqsyseylkdfwgnplmyn
keyymfnagnknsyiklkkdspvgeiltrskynqnskyinyrdlyigekfiirrksnddi
vrkedyiyldffnlnqewrvytykyfkkeeeklflapisdsdefyntiqikeydeqptys
cqllfkkdeestdeigligihrfyesgivfeeykdyfciskwylkevkrkpynlklgcnw
qfipkdegwte

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6uhtB (B:)
gplgseilnniilnlrykdnnlidlsgygakvevydgvelndknqfkltssanskirvtq
nqniifnsvfldfsvsfwiripkykndgiqnyihneytiincmknnsgwkisirgnriiw
tlidingktksvffeynirediseyinrwffvtitnnlnnakiyingklesntdikdire
viangeiifkldgdidrtqfiwmkyfsifntelsqsnieerykiqsyseylkdfwgnplm
ynkeyymfnagnknsyiklkkdspvgeiltrskynqnskyinyrdlyigekfiirrksns
qsinddivrkedyiyldffnlnqewrvytykyfkkeeeklflapisdsdefyntiqikey
deqptyscqllfkkdeestdeigligihrfyesgivfeeykdyfciskwylkevkrkpyn
lklgcnwqfipkdegwte

    Sequence, based on observed residues (ATOM records): (download) 
    >6uhtB (B:)
nniilnlrykdnnlidlsgygakvevydgvelndknqfkltssanskirvtqnqnivfld
fsvsfwiripkykndgiqnyihneytiincmknnsgwkisirgnriiwtlidingktksv
ffeynirediseyinrwffvtitnnlnnakiyingklesntdikdireviangeiifkld
gdidrtqfiwmkyfsifntelsqsnieerykiqsyseylkdfwgnplmynkeyymfnagn
knsyiklkkdspvgeiltrskynqnskyinyrdlyigekfiirrksnddivrkedyiyld
ffnlnqewrvytykyfkkeeeklflapisdsdefyntiqikeydeqptyscqllfkkdee
stdeigligihrfyesgivfeeykdyfciskwylkevkrkpynlklgcnwqfipkdegwt
e

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6uhtC (C:)
gplgsqvqlvesggglvqaggslrlscaasiltydldyyyigwvrqapgkeregvsciss
tdgatyyadsvkgrftisrnnakntvylqmnnlkpedtaiyycaaaplagrycpasheyg
ywgqgtqvtvssahhsedps

    Sequence, based on observed residues (ATOM records): (download) 
    >6uhtC (C:)
vesggglvqaggslrlscaasiltydldyyyigwvrqapgkeregvscisstdgatyyad
svkgrftisrnnakntvylqmnnlkpedtaiyycaaaplagrycpasheygywgqgtqvt
vssa

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6uhtD (D:)
gplgsqvqlvesggglvqaggslrlscaasiltydldyyyigwvrqapgkeregvsciss
tdgatyyadsvkgrftisrnnakntvylqmnnlkpedtaiyycaaaplagrycpasheyg
ywgqgtqvtvssahhsedps

    Sequence, based on observed residues (ATOM records): (download) 
    >6uhtD (D:)
plgsqvqlvesggglvqaggslrlscaasiltydldyyyigwvrqapgkeregvscisst
dgatyyadsvkgrftisrnnakntvylqmnnlkpedtaiyycaaaplagrycpasheygy
wgqgtqvtvs