PDB entry 6tlc

View 6tlc on RCSB PDB site
Description: Unphosphorylated human STAT3 in complex with MS3-6 monobody
Class: transcription
Keywords: Inhibitor, Complex, STAT3, Monobody, TRANSCRIPTION
Deposited on 2019-12-02, released 2020-07-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-26, with a file datestamp of 2020-08-21.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Signal transducer and activator of transcription 3
    Species: Homo sapiens [TaxId:9606]
    Gene: Stat3, Aprf
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6tlca1, d6tlca2, d6tlca3
  • Chain 'B':
    Compound: Signal transducer and activator of transcription 3
    Species: Homo sapiens [TaxId:9606]
    Gene: Stat3, Aprf
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6tlcb1, d6tlcb2, d6tlcb3
  • Chain 'C':
    Compound: monobody
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6TLC (0-94)
    Domains in SCOPe 2.08: d6tlcc_
  • Chain 'D':
    Compound: monobody
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6TLC (0-94)
    Domains in SCOPe 2.08: d6tlcd_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6tlcA (A:)
gsgqanhptaavvtekqqmleqhlqdvrkrvqdleqkmkvvenlqddfdfnyktlksqgd
mqdlngnnqsvtrqkmqqleqmltaldqmrrsivselagllsameyvqktltdeeladwk
rrqqiaciggppnicldrlenwitslaesqlqtrqqikkleelqqkvsykgdpivqhrpm
leerivelfrnlmksafvverqpcmpmhpdrplviktgvqfttkvrllvkfpelnyqlki
kvcidkdsgdvaalrgsrkfnilgtntkvmnmeesnngslsaefkhltlreqrcgnggra
ncdaslivteelhlitfetevyhqglkidlethslpvvvisnicqmpnawasilwynmlt
nnpknvnfftkppigtwdqvaevlswqfssttkrglsieqlttlaekllgpgvnysgcqi
twakfckenmagkgfsfwvwldniidlvkkyilalwnegyimgfiskererailstkppg
tfllrfsesskeggvtftwvekdisgktqiqsvepytkqqlnnmsfaeiimgykimdatn
ilvsplvylypdipkeeafgkycrpesqehpeadpgsaapylktkficvtpttcsnti

    Sequence, based on observed residues (ATOM records): (download) 
    >6tlcA (A:)
vvtekqqmleqhlqdvrkrvqdleqkmkvvenlqddfdfnyktlksqgdmqdlngnnqsv
trqkmqqleqmltaldqmrrsivselagllsameyvqktltdeeladwkrrqqiaciggp
pnicldrlenwitslaesqlqtrqqikkleelqqkvsykgdpivqhrpmleerivelfrn
lmksafvverqpcmpmhpdrplviktgvqfttkvrllvkfpelnyqlkikvcidkdrkfn
ilgtntkvmnmeenngslsaefkhltlreqraslivteelhlitfetevyhqglkidlet
hslpvvvisnicqmpnawasilwynmltnnpknvnfftkppigtwdqvaevlswqfsstt
krglsieqlttlaekllgpgvnysgcqitwakfckenmagkgfsfwvwldniidlvkkyi
lalwnegyimgfiskererailstkppgtfllrfsesskeggvtftwvekdisgktqiqs
vepytkqqlnnmsfaeiimgykimdatnilvsplvylypdipkeeafgkycrp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6tlcB (B:)
gsgqanhptaavvtekqqmleqhlqdvrkrvqdleqkmkvvenlqddfdfnyktlksqgd
mqdlngnnqsvtrqkmqqleqmltaldqmrrsivselagllsameyvqktltdeeladwk
rrqqiaciggppnicldrlenwitslaesqlqtrqqikkleelqqkvsykgdpivqhrpm
leerivelfrnlmksafvverqpcmpmhpdrplviktgvqfttkvrllvkfpelnyqlki
kvcidkdsgdvaalrgsrkfnilgtntkvmnmeesnngslsaefkhltlreqrcgnggra
ncdaslivteelhlitfetevyhqglkidlethslpvvvisnicqmpnawasilwynmlt
nnpknvnfftkppigtwdqvaevlswqfssttkrglsieqlttlaekllgpgvnysgcqi
twakfckenmagkgfsfwvwldniidlvkkyilalwnegyimgfiskererailstkppg
tfllrfsesskeggvtftwvekdisgktqiqsvepytkqqlnnmsfaeiimgykimdatn
ilvsplvylypdipkeeafgkycrpesqehpeadpgsaapylktkficvtpttcsnti

    Sequence, based on observed residues (ATOM records): (download) 
    >6tlcB (B:)
vvtekqqmleqhlqdvrkrvqdleqkmkvvenlqddfdfnyktlksqgdmqdlnnqsvtr
qkmqqleqmltaldqmrrsivselagllsameyvqktltdeeladwkrrqqiaciggppn
icldrlenwitslaesqlqtrqqikkleelqqkvsykgdpivqhrpmleerivelfrnlm
ksafvverqpcmpmhpdrplviktgvqfttkvrllvkfpelnyqlkikvcidkdrgsrkf
nilgtntkvmnmeesnngslsaefkhltlreqrcgslivteelhlitfetevyhqglkid
lethslpvvvisnicqmpnawasilwynmltnnpknvnfftkppigtwdqvaevlswqfs
sttkrglsieqlttlaekllgpgvnysgcqitwakfckenmagkgfsfwvwldniidlvk
kyilalwnegyimgfiskererailstkppgtfllrfsesskeggvtftwvekdisgktq
iqsvepytkqqlnnmsfaeiimgykimdatnilvsplvylypdipkeeafgkycr

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6tlcC (C:)
gsvssvptklevvaatptslliswdapavtvdfyhitygetggnspvqeftvpgskstat
isglkpgvdytitvyayvsypeyyfpspisinyrt

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6tlcD (D:)
gsvssvptklevvaatptslliswdapavtvdfyhitygetggnspvqeftvpgskstat
isglkpgvdytitvyayvsypeyyfpspisinyrt