PDB entry 6t6r

View 6t6r on RCSB PDB site
Description: Human endoplasmic reticulum aminopeptidase 1 (ERAP1) in complex with (4aR,5S,6R,8S,8aR)-5-(2-(Furan-3-yl)ethyl)-8-hydroxy-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid
Class: hydrolase
Keywords: ERAP1, Aminopeptidase, hydrolase
Deposited on 2019-10-18, released 2020-03-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-08, with a file datestamp of 2020-04-03.
Experiment type: XRAY
Resolution: 1.67 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: endoplasmic reticulum aminopeptidase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP1, APPILS, ARTS1, KIAA0525, UNQ584/PRO1154
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NZ08
      • engineered mutation (69)
      • engineered mutation (153)
      • engineered mutation (413)
      • engineered mutation (734)
    Domains in SCOPe 2.08: d6t6ra1, d6t6ra2, d6t6ra3, d6t6ra4
  • Heterogens: MNZ, ZN, MLT, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6t6rA (A:)
mvflplkwslatmsfllssllalltvstpswcqsteaspkrsdgtpfpwnkirlpeyvip
vhydllihaqlttltfwgttkveitasqptstiilhshhlqisratlrkgagerlseepl
qvlehprqeqiallapepllvglpytvvihyagqlsetfhgfykstyrtkegelrilast
qfeptaarmafpcfdepafkasfsikirreprhlaisnmplvksvtvaegliedhfdvtv
kmstylvafiisdfesvskitksgvkvsvyavpdkinqadyaldaavtllefyedyfsip
yplpkqdlaaipdfqsgamenwglttyresallfdaekssassklgitmtvahelahqwf
gnlvtmewwndlwlnegfakfmefvsvsvthpelkvgdyffgkcfdamevdalqsshpvs
tpvenpaqiremfddvsydkgacilnmlreylsadafksgivqylqkhsykntknedlwd
smasigsggvdvktmmntwtlqkgfplititvrgrnvhmkqehymkgsdgapdtgylwhv
pltfitsksdmvhrfllktktdvlilpeevewikfnvgmngyyivhyeddgwdsltgllk
gthtavssndraslinnafqlvsigklsiekaldlslylkheteimpvfqglnelipmyk
lmekrdmnevetqfkaflirllrdlidkqtwtdegsvsermlrsqllllacvhnyqpcvq
raegyfrkwkesngqlslpvdvtlavfavgaqstegwdflyskyqfslssteksqiefal
crtqnkeklqwlldesfkgdkiktqefpqiltligrnpvgyplawqflrknwnklvqkfe
lgsssiahmvmgttnqfstrtrleevkgffsslkengsqlrcvqqtietieenigwmdkn
fdkirvwlqseklermenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6t6rA (A:)
tpfpwnkirlpeyvipvhydllihaqlttltfwgttkveitasqptstiilhshhlqisr
atlrkgagerlseeplqvlehprqeqiallapepllvglpytvvihyagqlsetfhgfyk
styrtkegelrilastqfeptaarmafpcfdepafkasfsikirreprhlaisnmplvks
vtvaegliedhfdvtvkmstylvafiisdfesvskitksgvkvsvyavpdkinqadyald
aavtllefyedyfsipyplpkqdlaaipdfqsgamenwglttyresallfdaekssassk
lgitmtvahelahqwfgnlvtmewwndlwlnegfakfmefvsvsvthpelkvgdyffgkc
fdamevdalqsshpvstpvenpaqiremfddvsydkgacilnmlreylsadafksgivqy
lqkhsykntknedlwdsmasigvdvktmmntwtlqkgfplititvrgrnvhmkqehymkg
gylwhvpltfitsksdmvhrfllktktdvlilpeevewikfnvgmngyyivhyeddgwds
ltgllkgthtavssndraslinnafqlvsigklsiekaldlslylkheteimpvfqglne
lipmyklmekrdmnevetqfkaflirllrdlidkqtwtdegsvsermlrsqllllacvhn
yqpcvqraegyfrkwkesngqlslpvdvtlavfavgaqstegwdflyskyqfslssteks
qiefalcrtqnkeklqwlldesfkgdkiktqefpqiltligrnpvgyplawqflrknwnk
lvqkfelgsssiahmvmgttnqfstrtrleevkgffsslkengsqlrcvqqtietieeni
gwmdknfdkirvwlqs