PDB entry 6sqo

View 6sqo on RCSB PDB site
Description: Crystal structure of human MDM2 RING domain homodimer bound to UbcH5B-Ub
Class: ligase
Keywords: Ubiquitin ligase, E3, MDM2, MDMX, E2, phosphorylation, p53, LIGASE
Deposited on 2019-09-04, released 2020-05-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-05-06, with a file datestamp of 2020-05-01.
Experiment type: XRAY
Resolution: 1.41 Å
R-factor: N/A
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: ubiquitin-conjugating enzyme e2 d2
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2D2, PUBC1, UBC4, UBC5B, UBCH4, UBCH5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62837 (0-145)
      • engineered mutation (20)
      • engineered mutation (83)
    Domains in SCOPe 2.07: d6sqob_
  • Chain 'C':
    Compound: Ubiquitin-40S ribosomal protein S27a
    Species: Homo sapiens [TaxId:9606]
    Gene: RPS27A
    Database cross-references and differences (RAF-indexed):
    • Uniprot J3QTR3 (1-76)
      • expression tag (0)
    Domains in SCOPe 2.07: d6sqoc1, d6sqoc2
  • Chain 'D':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: ubiquitin-conjugating enzyme e2 d2
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2D2, PUBC1, UBC4, UBC5B, UBCH4, UBCH5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62837 (0-145)
      • engineered mutation (20)
      • engineered mutation (83)
    Domains in SCOPe 2.07: d6sqoe_
  • Chain 'F':
    Compound: Ubiquitin-40S ribosomal protein S27a
    Species: Homo sapiens [TaxId:9606]
    Gene: RPS27A
    Database cross-references and differences (RAF-indexed):
    • Uniprot J3QTR3 (1-76)
      • expression tag (0)
    Domains in SCOPe 2.07: d6sqof1, d6sqof2
  • Heterogens: ZN, CL, NO3, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6sqoB (B:)
    alkrihkelndlardppaqcragpvgddmfhwqatimgpndspyqggvffltihfptdyp
    fkppkvafttriyhpninsngsikldilrsqwspaltiskvllsicsllcdpnpddplvp
    eiariyktdrekynriarewtqkyam
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6sqoC (C:)
    smqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdy
    niqkestlhlvlrlrgg
    

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6sqoE (E:)
    alkrihkelndlardppaqcragpvgddmfhwqatimgpndspyqggvffltihfptdyp
    fkppkvafttriyhpninsngsikldilrsqwspaltiskvllsicsllcdpnpddplvp
    eiariyktdrekynriarewtqkyam
    

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6sqoF (F:)
    smqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdy
    niqkestlhlvlrlrgg