PDB entry 6rsy

View 6rsy on RCSB PDB site
Description: The complex between TCR a7b2 and human Class I MHC HLA-A0201-WT1 with the bound RMFPNAPYL peptide.
Class: immune system
Keywords: MHC CLASS I ANTIGEN- TCR - peptide complex, IMMUNE SYSTEM
Deposited on 2019-05-22, released 2020-04-15
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-04-15, with a file datestamp of 2020-04-10.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6rsya1, d6rsya2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d6rsyb1, d6rsyb2
  • Chain 'C':
    Compound: arg-met-phe-pro-asn-ala-pro-tyr-leu
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RSY (0-8)
  • Chain 'D':
    Compound: a7b2 ALPHA CHAIN
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RSY
    Domains in SCOPe 2.07: d6rsyd1, d6rsyd2
  • Chain 'E':
    Compound: DMF4 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RSY (Start-244)
    Domains in SCOPe 2.07: d6rsye1, d6rsye2
  • Chain 'F':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6rsyf1, d6rsyf2
  • Chain 'G':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d6rsyg1, d6rsyg2
  • Chain 'H':
    Compound: arg-met-phe-pro-asn-ala-pro-tyr-leu
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RSY (0-8)
  • Chain 'I':
    Compound: a7b2 ALPHA CHAIN
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RSY
    Domains in SCOPe 2.07: d6rsyi1, d6rsyi2
  • Chain 'J':
    Compound: DMF4 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RSY (Start-244)
    Domains in SCOPe 2.07: d6rsyj1, d6rsyj2
  • Heterogens: EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6rsyA (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwep
    

    Sequence, based on observed residues (ATOM records): (download)
    >6rsyA (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6rsyB (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >6rsyD (D:)
    madakttqppsmdcaegraanlpcnhstvdpneyvywyrqihsqgpqyiihglknnetne
    masliitedrksstlilphatlrdtavyycigggttsgtykyifgtgtrlkvlaniqnpd
    pavyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavaws
    nksdfacanafnnsiipedtffpspess
    

    Sequence, based on observed residues (ATOM records): (download)
    >6rsyD (D:)
    dakttqppsmdcaegraanlpcnhstvdpneyvywyrqihsqgpqyiihglknnetnema
    sliitedrksstlilphatlrdtavyycigggttsgtykyifgtgtrlkvlaniqnpdpa
    vyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnk
    sdfacanafnns
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >6rsyE (E:)
    mdtgvsqdprhkitkrgqnvtfrcdpisehnrlywyrqtlgqgpefltyfqneaqleksr
    llsdrfsaerpkgsfstleiqrteqgdsamylcasslgfgrdvmrfgpgtrllvledlkn
    vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
    qpalndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaet
    wgrad
    

    Sequence, based on observed residues (ATOM records): (download)
    >6rsyE (E:)
    gvsqdprhkitkrgqnvtfrcdpisehnrlywyrqtlgqgpefltyfqneaqleksrlls
    drfsaerpkgsfstleiqrteqgdsamylcasslgfgrdvmrfgpgtrllvledlknvfp
    pevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpa
    lndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaetwgr
    ad
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >6rsyF (F:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwep
    

    Sequence, based on observed residues (ATOM records): (download)
    >6rsyF (F:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrw
    

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6rsyG (G:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >6rsyI (I:)
    madakttqppsmdcaegraanlpcnhstvdpneyvywyrqihsqgpqyiihglknnetne
    masliitedrksstlilphatlrdtavyycigggttsgtykyifgtgtrlkvlaniqnpd
    pavyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavaws
    nksdfacanafnnsiipedtffpspess
    

    Sequence, based on observed residues (ATOM records): (download)
    >6rsyI (I:)
    adakttqppsmdcaegraanlpcnhstvdpneyvywyrqihsqgpqyiihglknnetnem
    asliitedrksstlilphatlrdtavyycigggttsgtykyifgtgtrlkvlaniqnpdp
    avyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsn
    ksdfacanafn
    

  • Chain 'J':
    Sequence, based on SEQRES records: (download)
    >6rsyJ (J:)
    mdtgvsqdprhkitkrgqnvtfrcdpisehnrlywyrqtlgqgpefltyfqneaqleksr
    llsdrfsaerpkgsfstleiqrteqgdsamylcasslgfgrdvmrfgpgtrllvledlkn
    vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
    qpalndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaet
    wgrad
    

    Sequence, based on observed residues (ATOM records): (download)
    >6rsyJ (J:)
    gvsqdprhkitkrgqnvtfrcdpisehnrlywyrqtlgqgpefltyfqneaqleksrlls
    drfsaerpkgsfstleiqrteqgdsamylcasslgfgrdvmrfgpgtrllvledlknvfp
    pevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpa
    lndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaetwgr
    ad