PDB entry 6rnk

View 6rnk on RCSB PDB site
Description: Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist NF-56-EJ40.
Class: membrane protein
Keywords: SUCNR1, GPR91, GPCR, G-Protein coupled receptor, Nanobody, Antagonist, Succinate, Complex, MEMBRANE PROTEIN
Deposited on 2019-05-08, released 2019-08-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-06, with a file datestamp of 2019-11-01.
Experiment type: XRAY
Resolution: 1.94 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Succinate receptor 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Sucnr1, Gpr91
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6IYF9
      • engineered mutation (24)
      • engineered mutation (275)
    Domains in SCOPe 2.08: d6rnka_
  • Chain 'B':
    Compound: Nanobody6
    Species: Vicugna pacos [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RNK
    Domains in SCOPe 2.08: d6rnkb1, d6rnkb2
  • Heterogens: KAZ, OLC, GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6rnkA (A:)
dykddddkaqnlscenwlalenilekyylsafygiefivgmlgnftvvfgylfcmknwns
snvylfnlsisdlaflctlpmlirsyatgnwtygdvlcisnryvlhanlytsilfltfis
idryllmkfpfrehilqkkefailislavwvlvtlevlpmltfitstpiekgdscvdyas
sgnpkysliyslcltllgfliplsvmcffyykmvvflkkrsqqqatvlslnkplrlvvla
vvifsvlftpyhimrnvriasrldswpqgcsqkainclyiltrplaflnsavnpifyflv
gdhfrdmlfsklrqyfksltsfrllevlfqgphhhhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6rnkA (A:)
cenwlalenilekyylsafygiefivgmlgnftvvfgylfcmknwnssnvylfnlsisdl
aflctlpmlirsyatgnwtygdvlcisnryvlhanlytsilfltfisidryllmkfpfre
hilqkkefailislavwvlvtlevlpmltfitstpiekgdscvdyassgnpkysliyslc
ltllgfliplsvmcffyykmvvflkkrsnkplrlvvlavvifsvlftpyhimrnvriasr
lgcsqkainclyiltrplaflnsavnpifyflvgdhfrdmlfskl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6rnkB (B:)
dykddddkevqlvesggglvqpggslrlsceasgytlanyaigwfrqapgkeregvscis
sggstvysesvkdrftisrdnakkivylqmnslqpedtavyycaadpfgerlcidpntfa
gyletwgqgtqvtvsslevlfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6rnkB (B:)
evqlvesggglvqpggslrlsceasgytlanyaigwfrqapgkeregvscissggstvys
esvkdrftisrdnakkivylqmnslqpedtavyycaadpfgerlcidpntfagyletwgq
gtqvtvssl