PDB entry 6q4r

View 6q4r on RCSB PDB site
Description: High-resolution crystal structure of ERAP1 with bound phosphinic transition-state analogue inhibitor
Class: hydrolase
Keywords: endoplasmic reticulum aminopeptidase 1, ERAP1, antigen presentation, hydrolase
Deposited on 2018-12-06, released 2019-04-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-04-10, with a file datestamp of 2019-04-05.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Endoplasmic reticulum aminopeptidase 1,Endoplasmic reticulum aminopeptidase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP1, APPILS, ARTS1, KIAA0525, UNQ584/PRO1154
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6q4ra1, d6q4ra2, d6q4ra3, d6q4ra4
  • Heterogens: HJ5, NAG, BMA, ZN, B3P, EDO, MLT, P6G, PG4, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6q4rA (A:)
mvflplkwslatmsfllssllalltvstpswcqsteaspkrsdgtpfpwnkirlpeyvip
vhydllihanlttltfwgttkveitasqptstiilhshhlqisratlrkgagerlseepl
qvlehprqeqiallapepllvglpytvvihyagnlsetfhgfykstyrtkegelrilast
qfeptaarmafpcfdepafkasfsikirreprhlaisnmplvksvtvaegliedhfdvtv
kmstylvafiisdfesvskitksgvkvsvyavpdkinqadyaldaavtllefyedyfsip
yplpkqdlaaipdfqsgamenwglttyresallfdaekssassklgitmtvahelahqwf
gnlvtmewwndlwlnegfakfmefvsvsvthpelkvgdyffgkcfdamevdalnsshpvs
tpvenpaqiremfddvsydkgacilnmlreylsadafksgivqylqkhsykntknedlwd
smasigsggvdvktmmntwtlqkgfplititvrgrnvhmkqehymkgsdgapdtgylwhv
pltfitsksdmvhrfllktktdvlilpeevewikfnvgmngyyivhyeddgwdsltgllk
gthtavssndraslinnafqlvsigklsiekaldlslylkheteimpvfqglnelipmyk
lmekrdmnevetqfkaflirllrdlidkqtwtdegsvsermlrsqllllacvhnyqpcvq
raegyfrkwkesngnlslpvdvtlavfavgaqstegwdflyskyqfslssteksqiefal
crtqnkeklqwlldesfkgdkiktqefpqiltligrnpvgyplawqflrknwnklvqkfe
lgsssiahmvmgttnqfstrtrleevkgffsslkengsqlrcvqqtietieenigwmdkn
fdkirvwlqsek

    Sequence, based on observed residues (ATOM records): (download) 
    >6q4rA (A:)
tpfpwnkirlpeyvipvhydllihanlttltfwgttkveitasqptstiilhshhlqisr
atlrkrlseeplqvlehprqeqiallapepllvglpytvvihyagnlsetfhgfykstyr
tkegelrilastqfeptaarmafpcfdepafkasfsikirreprhlaisnmplvksvtva
egliedhfdvtvkmstylvafiisdfesvskitksgvkvsvyavpdkinqadyaldaavt
llefyedyfsipyplpkqdlaaipdfqsgamenwglttyresallfdaekssassklgit
mtvahelahqwfgnlvtmewwndlwlnegfakfmefvsvsvthpelkvgdyffgkcfdam
evdalnsshpvstpvenpaqiremfddvsydkgacilnmlreylsadafksgivqylqkh
sykntknedlwdsmasivdvktmmntwtlqkgfplititvrgrnvhmkqehymkgdtgyl
whvpltfitsksdmvhrfllktktdvlilpeevewikfnvgmngyyivhyeddgwdsltg
llkgthtavssndraslinnafqlvsigklsiekaldlslylkheteimpvfqglnelip
myklmekrdmnevetqfkaflirllrdlidkqtwtdegsvsermlrsqllllacvhnyqp
cvqraegyfrkwkesngnlslpvdvtlavfavgaqstegwdflyskyqfslssteksqie
falcrtqnkeklqwlldesfkgdkiktqefpqiltligrnpvgyplawqflrknwnklvq
kfelgsssiahmvmgttnqfstrtrleevkgffsslkengsqlrcvqqtietieenigwm
dknfdkirvwlqsek