PDB entry 6p68

View 6p68 on RCSB PDB site
Description: Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 22.
Class: transferase
Keywords: TRANSFERASE-TRANSFER complex, TRANSFERASE
Deposited on 2019-06-03, released 2019-06-19
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-06-19, with a file datestamp of 2019-06-14.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • engineered mutation (31)
      • engineered mutation (106)
    Domains in SCOPe 2.07: d6p68a_
  • Chain 'B':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • engineered mutation (31)
      • engineered mutation (106)
    Domains in SCOPe 2.07: d6p68b_
  • Chain 'C':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • engineered mutation (31)
      • engineered mutation (106)
    Domains in SCOPe 2.07: d6p68c_
  • Heterogens: O1Y, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6p68A (A:)
    gagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkml
    ksdatekdlsdlisememmkmigkhkniinllgactqdgplyvivecaskgnlreylqar
    rppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednv
    mkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftl
    ggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldr
    ivaltsnqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >6p68A (A:)
    eyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdat
    ekdlsdlisememmkmigkhkniinllgactqdgplyvivecaskgnlreylqarrppee
    qlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglardidyykk
    ttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeg
    hrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsn
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6p68B (B:)
    gagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkml
    ksdatekdlsdlisememmkmigkhkniinllgactqdgplyvivecaskgnlreylqar
    rppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednv
    mkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftl
    ggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldr
    ivaltsnqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >6p68B (B:)
    eyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdat
    ekdlsdlisememmkmigkhkniinllgactqdgplyvivecaskgnlreylqarrpeeq
    lsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglardidyykkt
    tngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkegh
    rmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsn
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6p68C (C:)
    gagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkml
    ksdatekdlsdlisememmkmigkhkniinllgactqdgplyvivecaskgnlreylqar
    rppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednv
    mkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftl
    ggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldr
    ivaltsnqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >6p68C (C:)
    yelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdate
    kdlsdlisememmkmigkhkniinllgactqdgplyvivecaskgnlreylqarrppeeq
    lsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglardidyykkt
    tngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkegh
    rmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsn