PDB entry 6otg

View 6otg on RCSB PDB site
Description: HIV-1 protease triple mutants V32I, I47V, V82I with GRL-011-11A (a methylamine bis-Tetrahydrofuran P2-Ligand, sulfonamide isostere derivate)
Class: HYDROLASE/HYDROLASE inhibitor
Keywords: HIV-1 protease; antiviral inhibitors; drug resistance; X-ray crystallography, HYDROLASE-HYDROLASE inhibitor complex
Deposited on 2019-05-03, released 2019-05-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q7SSI0 (0-98)
    • engineered mutation (6)
    • engineered mutation (31-32)
    • engineered mutation (46)
    • engineered mutation (62)
    • engineered mutation (66)
    • engineered mutation (81)
    • engineered mutation (94)
  Domains in SCOPe 2.08: d6otga_
• Chain 'B':
  Compound: Protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q7SSI0 (0-98)
    • engineered mutation (6)
    • engineered mutation (31-32)
    • engineered mutation (46)
    • engineered mutation (62)
    • engineered mutation (66)
    • engineered mutation (81)
    • engineered mutation (94)
  Domains in SCOPe 2.08: d6otgb_
• Heterogens: 4UY, FMT, GOL, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6otgA (A:)
  pqitlwkrplvtikiggqlkealldtgaddtiieemslpgrwkpkmvggiggfikvrqyd
  qiiieiaghkaigtvlvgptpiniigrnlltqigatlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6otgB (B:)
  pqitlwkrplvtikiggqlkealldtgaddtiieemslpgrwkpkmvggiggfikvrqyd
  qiiieiaghkaigtvlvgptpiniigrnlltqigatlnf