PDB entry 6oqi

View 6oqi on RCSB PDB site
Description: CDK2 in complex with Cpd14 (5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl)-N-(5-(4-methylpiperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine)
Class: TRANSFERASE/TRANSFERASE inhibitor
Keywords: kinase, TRANSFERASE, TRANSFERASE-TRANSFERASE inhibitor complex
Deposited on 2019-04-26, released 2020-07-29
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-24.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2, CDKN2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (1-298)
      • expression tag (0)
    Domains in SCOPe 2.07: d6oqia1, d6oqia2
  • Heterogens: N14, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6oqiA (A:)
    fmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
    hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
    shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
    ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
    fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
    

    Sequence, based on observed residues (ATOM records): (download)
    >6oqiA (A:)
    fmenfqkvekigegtygvvykarnkltgevvalkkirltaireisllkelnhpnivklld
    vihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdl
    kpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyystavdiws
    lgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdf
    skvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl