PDB entry 6naj

View 6naj on RCSB PDB site
Description: Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin.
Class: cell adhesion
Keywords: hybrid domain, psi, egf repeats, beta tail, calf, thigh, beta propeller, rgd motif, fibronectin, vitronectin, cell adhesion
Deposited on 2018-12-05, released 2019-12-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Integrin alpha-V
    Species: Homo sapiens [TaxId:9606]
    Gene: ITGAV, MSK8, VNRA, VTNR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6naja1, d6naja2, d6naja3, d6naja4
  • Chain 'B':
    Compound: integrin beta-3
    Species: Homo sapiens [TaxId:9606]
    Gene: ITGB3, GP3A
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Fibronectin, HR10 variant
    Species: Homo sapiens [TaxId:9606]
    Gene: FN1, FN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02751 (0-89)
      • conflict (75)
      • conflict (79-83)
    Domains in SCOPe 2.08: d6najc_
  • Heterogens: NAG, MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6najA (A:)
fnldvdspaeysgpegsyfgfavdffvpsassrmfllvgapkanttqpgiveggqvlkcd
wsstrrcqpiefdatgnrdyakddplefkshqwfgasvrskqdkilacaplyhwrtemkq
erepvgtcflqdgtktveyapcrsqdidadgqgfcqggfsidftkadrvllggpgsfywq
gqlisdqvaeivskydpnvysikynnqlatrtaqaifddsylgysvavgdfngdgiddfv
sgvpraartlgmvyiydgknmsslynftgeqmaayfgfsvaatdingddyadvfigaplf
mdrgsdgklqevgqvsvslqrasgdfqttklngfevfarfgsaiaplgdldqdgfndiai
aapyggedkkgivyifngrstglnavpsqilegqwaarsmppsfgysmkgatdidkngyp
dlivgafgvdrailyrarpvitvnaglevypsilnqdnktcslpgtalkvscfnvrfclk
adgkgvlprklnfqvellldklkqkgairralflysrspshsknmtisrgglmqceelia
ylrdesefrdkltpitifmeyrldyrtaadttglqpilnqftpanisrqahilldcgedn
vckpklevsvdsdqkkiyigddnpltlivkaqnqgegayeaelivsiplqadfigvvrnn
ealarlscafktenqtrqvvcdlgnpmkagtqllaglrfsvhqqsemdtsvkfdlqiqss
nlfdkvspvvshkvdlavlaaveirgvsspdhvflpipnwehkenpeteedvgpvvqhiy
elrnngpssfskamlhlqwpykynnntllyilhydidgpmnctsdmeinplrikisslqt
tekndtvagqgerdhlitkrdlalsegdihtlgcgvaqclkivcqvgrldrgksailyvk
sllwtetfmnkenqnhsyslkssasfnviefpyknlpieditnstlvttnvtwg

    Sequence, based on observed residues (ATOM records): (download) 
    >6najA (A:)
fnldvdspaeysgpegsyfgfavdffvpsassrmfllvgapkanttqpgiveggqvlkcd
wsstrrcqpiefdatgnrdyakddplefkshqwfgasvrskqdkilacaplyhwrtemkq
erepvgtcflqdgtktveyapcrsqdidadgqgfcqggfsidftkadrvllggpgsfywq
gqlisdqvaeivskydpnvysikynnqlatrtaqaifddsylgysvavgdfngdgiddfv
sgvpraartlgmvyiydgknmsslynftgeqmaayfgfsvaatdingddyadvfigaplf
mdrgsdgklqevgqvsvslqrasgdfqttklngfevfarfgsaiaplgdldqdgfndiai
aapyggedkkgivyifngrstglnavpsqilegqwaarsmppsfgysmkgatdidkngyp
dlivgafgvdrailyrarpvitvnaglevypsilnqdnktcslpgtalkvscfnvrfclk
adgkgvlprklnfqvellldklkqkgairralflysrspshsknmtisrgglmqceelia
ylrdesefrdkltpitifmeyrldyrtaadttglqpilnqftpanisrqahilldcgedn
vckpklevsvdsdqkkiyigddnpltlivkaqnqgegayeaelivsiplqadfigvvrnn
ealarlscafktenqtrqvvcdlgnpmkagtqllaglrfsvhqqsemdtsvkfdlqiqss
nlfdkvspvvshkvdlavlaaveirgvsspdhvflpipnwehkenpeteedvgpvvqhiy
elrnngpssfskamlhlqwpykynnntllyilhydidgpmnctsdmeinplrikihtlgc
gvaqclkivcqvgrldrgksailyvksllwtetfmnkenqnhsyslkssasfnviefpyk
nlpieditnstlvttnvtwg

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6najC (C:)
sdvprdlevvaatptslliswdapavtvryyritygetggnspvqeftvpgskstatisg
lkpgvdytitvyavtprgdwneggpisiny