PDB entry 6mzq

View 6mzq on RCSB PDB site
Description: TAS-120 in reversible binding mode with FGFR1
Class: TRANSFERASE/TRANSFERASE Inhibitor
Keywords: FGFR1, TAS-120, inhibitor, complex, TRANSFERASE, TRANSFERASE-TRANSFERASE Inhibitor complex
Deposited on 2018-11-05, released 2019-01-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-01-16, with a file datestamp of 2019-01-11.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362 (Start-310)
      • conflict (129)
    Domains in SCOPe 2.07: d6mzqa_
  • Chain 'B':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6mzqb_
  • Heterogens: TZ0, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6mzqA (A:)
    gamsgvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavk
    mlksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylq
    arrppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvted
    nvmkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweif
    tlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedl
    drivaltsnqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >6mzqA (A:)
    elpedprwelprdrlvlgkplgegqvvlaeaigldkdkpnrvtkvavkmlksdatekdls
    dlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppgleysyn
    pseeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglpvkwm
    apealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkpsnctn
    elymmmrdcwhavpsqrptfkqlvedldrivaltsqe
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6mzqB (B:)
    gamsgvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavk
    mlksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylq
    arrppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvted
    nvmkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweif
    tlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedl
    drivaltsnqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >6mzqB (B:)
    eyelpedprwelprdrlvlgkplgegqvvlaeaigldkdkpnrvtkvavkmlksdatekd
    lsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarlsskdlvs
    cayqvargmeylaskkcihrdlaarnvlvtednvmkiadfgpvkwmapealfdriythqs
    dvwsfgvllweiftlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavp
    sqrptfkqlvedldrivalt