PDB entry 6mxe

View 6mxe on RCSB PDB site
Description: Crystal structure of human STING (G230A, H232R, R293Q) in complex with Compound 18
Class: immune system/inhibitor
Keywords: INNATE IMMUNITY, SIGNALING, OPEN CONFORMATION, IMMUNE SYSTEM, immune system-inhibitor complex
Deposited on 2018-10-30, released 2018-12-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-01-30, with a file datestamp of 2019-01-25.
Experiment type: XRAY
Resolution: 2.47 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Stimulator of interferon genes protein
    Species: Homo sapiens [TaxId:9606]
    Gene: TMEM173, ERIS, MITA, STING
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q86WV6 (1-End)
      • expression tag (0)
      • engineered mutation (139)
    Domains in SCOPe 2.08: d6mxea1, d6mxea2
  • Chain 'B':
    Compound: Stimulator of interferon genes protein
    Species: Homo sapiens [TaxId:9606]
    Gene: TMEM173, ERIS, MITA, STING
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q86WV6 (1-End)
      • expression tag (0)
      • engineered mutation (139)
    Domains in SCOPe 2.08: d6mxeb1, d6mxeb2
  • Heterogens: K5S, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6mxeA (A:)
svahglawsyyigylrlilpelqarirtynqhynnllrgavsqrlyillpldcgvpdnls
madpnirfldklpqqtadragikdrvysnsiyellengqragtcvleyatplqtlfamsq
ysqagfsredrleqaklfcqtlediladapesqnncrliayqepaddssfslsqevlrhl
rqeekeev

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxeA (A:)
svahglawsyyigylrlilpelqarirtynqhynnllrgavsqrlyillpldcgvpdnls
madpnirfldklpqsnsiyellengqragtcvleyatplqtlfamsqysqagfsredrle
qaklfcqtlediladapesqnncrliayqesfslsqevlrhlrq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6mxeB (B:)
svahglawsyyigylrlilpelqarirtynqhynnllrgavsqrlyillpldcgvpdnls
madpnirfldklpqqtadragikdrvysnsiyellengqragtcvleyatplqtlfamsq
ysqagfsredrleqaklfcqtlediladapesqnncrliayqepaddssfslsqevlrhl
rqeekeev

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxeB (B:)
svahglawsyyigylrlilpelqarirtynqhynnllrgavsqrlyillpldcgvpdnls
madpnirfldklpqsnsiyellengqragtcvleyatplqtlfamsqysqagfsredrle
qaklfcqtlediladapesqnncrliayqepaddssfslsqevlrhlrq