PDB entry 6mvl

View 6mvl on RCSB PDB site
Description: Crystal structure of VISTA bound to a pH-selective antibody Fab fragment
Class: immune system
Keywords: immunoglobulin, checkpoint, antibody, complex, IMMUNE SYSTEM
Deposited on 2018-10-26, released 2019-10-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 1.61 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: V-type immunoglobulin domain-containing suppressor of T-cell activation
    Species: Homo sapiens [TaxId:9606]
    Gene: VSIR, C10orf54, SISP1, VISTA, PP2135, UNQ730/PRO1412
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9H7M9
      • engineered mutation (59)
  • Chain 'H':
    Compound: antibody fab fragment heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MVL (0-End)
    Domains in SCOPe 2.08: d6mvlh_
  • Chain 'L':
    Compound: antibody fab fragment light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MVL (0-End)
    Domains in SCOPe 2.08: d6mvll1, d6mvll2
  • Heterogens: NAG, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6mvlH (H:)
evqlvesggglvqpgkslrlscaasgftledyamhwvrqapgkglewvsgidwnsenigy
adsvkgrftisrdnaknslylqmnslrtedtalyycakvpgysggwidaeddwgqgtmvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkt

    Sequence, based on observed residues (ATOM records): (download) 
    >6mvlH (H:)
evqlvesggglvqpgkslrlscaasgftledyamhwvrqapgkglewvsgidwnsenigy
adsvkgrftisrdnaknslylqmnslrtedtalyycakvpgysggwidaeddwgqgtmvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepk

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6mvlL (L:)
eivltqspgtlslspgeratlscrasqsvsssylawyqqkpgqaprlliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqygsspftfgpgtkvdikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6mvlL (L:)
eivltqspgtlslspgeratlscrasqsvssylawyqqkpgqaprlliygassratgipd
rfsgsgsgtdftltisrlepedfavyycqqygsspftfgpgtkvdikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge