PDB entry 6mtn

View 6mtn on RCSB PDB site
Description: Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor Compound 484 in Complex with Human Antibodies 3H109L and 35O22 at 3.0 Angstrom
Class: immune system/inhibitor
Keywords: HIV-1 Envelope Prefusion Trimer, Entry Inhibitors, IMMUNE SYSTEM-INHIBITOR complex
Deposited on 2018-10-20, released 2019-01-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • engineered mutation (93)
  • Chain 'D':
    Compound: 35O22 scFv heavy chain portion
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MTN (0-End)
    Domains in SCOPe 2.08: d6mtnd_
  • Chain 'E':
    Compound: 35O22 scFv light chain portion
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MTN
    Domains in SCOPe 2.08: d6mtne_
  • Chain 'G':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • engineered mutation (106)
      • conflict (300)
      • conflict (468)
  • Chain 'H':
    Compound: 3H109L Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MTN (0-End)
    Domains in SCOPe 2.08: d6mtnh1, d6mtnh2
  • Chain 'L':
    Compound: 3H109L Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MTN
    Domains in SCOPe 2.08: d6mtnl1, d6mtnl2
  • Heterogens: JYJ, NAG, HOH

PDB Chain Sequences:

  • Chain 'B':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6mtnD (D:)
qgqlvqsgatttkpgssvkiscktsgyrfnfyhinwirqtagrgpewmgwispysgdknl
apafqdrvnmttdtevpvtsftstgaaymeirnltsddtgtyfcakgllrdgsstwlpyl
wgqgtlltvssast

    Sequence, based on observed residues (ATOM records): (download) 
    >6mtnD (D:)
qgqlvqsgatttkpgssvkiscktsgyrfnfyhinwirqtagrgpewmgwispysgdknl
apafqdrvnmttdtevpvtsftstgaaymeirnltsddtgtyfcakgllrdgsstwlpyl
wgqgtllt

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6mtnE (E:)
sqsvltqsasvsgslgqsvtisctgpnsvccshksiswyqwppgraptliiyednerapg
isprfsgyksywsayltisdlrpedettyyccsythnsgcvfgtgtkvsvlgqs

    Sequence, based on observed residues (ATOM records): (download) 
    >6mtnE (E:)
vltqsasvsgslgqsvtisctgpnsvccshksiswyqwppgraptliiyednerapgisp
rfsgyksywsayltisdlrpedettyyccsythnsgcvfgtgtkv

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6mtnH (H:)
qvqlqesgpglvkpsetlsltctvsggsisnyywswirqspgkglewigyisdsestnyn
pslksrviisvdtsknqlslklnsvtaadsaiyycaraqqgkriygmvsfgeffyyyymd
vwgkgttvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgalts
gvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkgle
vlfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6mtnH (H:)
qvqlqesgpglvkpsetlsltctvsggsisnyywswirqspgkglewigyisdsestnyn
pslksrviisvdtsknqlslklnsvtaadsaiyycaraqqgkriygmvsfgeffyyyymd
vwgkgttvtvssastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfp
avlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6mtnL (L:)
svtsyvrplsvalgetasiscgrqalgsravqwyqhrpgqapilliynnqdrpsgiperf
sgtpdinfgtratltisgveagdeadyychmwdsrsgfswsfggatrltvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpmqwkmhksyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >6mtnL (L:)
syvrplsvalgetasiscgrqalgsravqwyqhrpgqapilliynnqdrpsgiperfsgt
pdinfgtratltisgveagdeadyychmwdsrsgfswsfggatrltvlgqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpmqwkmhksyscqvthegstvektvapt