PDB entry 6mtn

View 6mtn on RCSB PDB site
Description: Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor Compound 484 in Complex with Human Antibodies 3H109L and 35O22 at 3.0 Angstrom
Class: immune system/inhibitor
Keywords: HIV-1 Envelope Prefusion Trimer, Entry Inhibitors, IMMUNE SYSTEM-INHIBITOR complex
Deposited on 2018-10-20, released 2019-01-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-01-16, with a file datestamp of 2019-01-11.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • engineered mutation (93)
  • Chain 'D':
    Compound: 35O22 scFv heavy chain portion
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MTN (0-End)
    Domains in SCOPe 2.07: d6mtnd_
  • Chain 'E':
    Compound: 35O22 scFv light chain portion
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MTN
    Domains in SCOPe 2.07: d6mtne_
  • Chain 'G':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • engineered mutation (106)
      • conflict (300)
      • conflict (468)
  • Chain 'H':
    Compound: 3H109L Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MTN (0-End)
  • Chain 'L':
    Compound: 3H109L Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MTN
    Domains in SCOPe 2.07: d6mtnl1, d6mtnl2
  • Heterogens: JYJ, NAG, BMA, MAN, HOH

PDB Chain Sequences:

  • Chain 'B':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >6mtnD (D:)
    qgqlvqsgatttkpgssvkiscktsgyrfnfyhinwirqtagrgpewmgwispysgdknl
    apafqdrvnmttdtevpvtsftstgaaymeirnltsddtgtyfcakgllrdgsstwlpyl
    wgqgtlltvssast
    

    Sequence, based on observed residues (ATOM records): (download)
    >6mtnD (D:)
    qgqlvqsgatttkpgssvkiscktsgyrfnfyhinwirqtagrgpewmgwispysgdknl
    apafqdrvnmttdtevpvtsftstgaaymeirnltsddtgtyfcakgllrdgsstwlpyl
    wgqgtllt
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >6mtnE (E:)
    sqsvltqsasvsgslgqsvtisctgpnsvccshksiswyqwppgraptliiyednerapg
    isprfsgyksywsayltisdlrpedettyyccsythnsgcvfgtgtkvsvlgqs
    

    Sequence, based on observed residues (ATOM records): (download)
    >6mtnE (E:)
    vltqsasvsgslgqsvtisctgpnsvccshksiswyqwppgraptliiyednerapgisp
    rfsgyksywsayltisdlrpedettyyccsythnsgcvfgtgtkv
    

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >6mtnL (L:)
    svtsyvrplsvalgetasiscgrqalgsravqwyqhrpgqapilliynnqdrpsgiperf
    sgtpdinfgtratltisgveagdeadyychmwdsrsgfswsfggatrltvlgqpkaapsv
    tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
    sylsltpmqwkmhksyscqvthegstvektvaptecs
    

    Sequence, based on observed residues (ATOM records): (download)
    >6mtnL (L:)
    syvrplsvalgetasiscgrqalgsravqwyqhrpgqapilliynnqdrpsgiperfsgt
    pdinfgtratltisgveagdeadyychmwdsrsgfswsfggatrltvlgqpkaapsvtlf
    ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
    sltpmqwkmhksyscqvthegstvektvapt