PDB entry 6mr5

View 6mr5 on RCSB PDB site
Description: Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with a mercaptoacetamide-based inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: histone deacetylase, zinc hydrolase, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2018-10-11, released 2018-12-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-12-05, with a file datestamp of 2018-11-30.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hdac6 protein
    Species: Danio rerio [TaxId:7955]
    Gene: HDAC6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6mr5a_
  • Chain 'B':
    Compound: Hdac6 protein
    Species: Danio rerio [TaxId:7955]
    Gene: HDAC6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6mr5b_
  • Heterogens: W45, ZN, K, PEG, FLC, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6mr5A (A:)
    snaggsspitglvydqrmmlhhnmwdshhpelpqrisrifsrheelrllsrchriparla
    teeelalchsskhisiikssehmkprdlnrlgdeynsifisnesytcallaagscfnsaq
    ailtgqvrnavaivrppghhaekdtacgfcffntaaltaryaqsitreslrvlivdwdvh
    hgngtqhifeeddsvlyislhryedgaffpnsedanydkvglgkgrgynvnipwnggkmg
    dpeymaafhhlvmpiarefapelvlvsagfdaargdplggfqvtpegyahlthqlmslaa
    grvliileggynltsisesmsmctsmllgdsppsldhltplktsatvsinnvlrahapfw
    sslr
    

    Sequence, based on observed residues (ATOM records): (download)
    >6mr5A (A:)
    pitglvydqrmmlhhnmwdshhpelpqrisrifsrheelrllsrchriparlateeelal
    chsskhisiikssehmkprdlnrlgdeynsifisnesytcallaagscfnsaqailtgqv
    rnavaivrppghhaekdtacgfcffntaaltaryaqsitreslrvlivdwdvhhgngtqh
    ifeeddsvlyislhryedgaffpnsedanydkvglgkgrgynvnipwnggkmgdpeymaa
    fhhlvmpiarefapelvlvsagfdaargdplggfqvtpegyahlthqlmslaagrvliil
    eggynltsisesmsmctsmllgdsppsldtplktsatvsinnvlrahapfwsslr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6mr5B (B:)
    snaggsspitglvydqrmmlhhnmwdshhpelpqrisrifsrheelrllsrchriparla
    teeelalchsskhisiikssehmkprdlnrlgdeynsifisnesytcallaagscfnsaq
    ailtgqvrnavaivrppghhaekdtacgfcffntaaltaryaqsitreslrvlivdwdvh
    hgngtqhifeeddsvlyislhryedgaffpnsedanydkvglgkgrgynvnipwnggkmg
    dpeymaafhhlvmpiarefapelvlvsagfdaargdplggfqvtpegyahlthqlmslaa
    grvliileggynltsisesmsmctsmllgdsppsldhltplktsatvsinnvlrahapfw
    sslr
    

    Sequence, based on observed residues (ATOM records): (download)
    >6mr5B (B:)
    spitglvydqrmmlhhnmwdshhpelpqrisrifsrheelrllsrchriparlateeela
    lchsskhisiikssehmkprdlnrlgdeynsifisnesytcallaagscfnsaqailtgq
    vrnavaivrppghhaekdtacgfcffntaaltaryaqsitreslrvlivdwdvhhgngtq
    hifeeddsvlyislhryedgaffpnsedanydkvglgkgrgynvnipwnggkmgdpeyma
    afhhlvmpiarefapelvlvsagfdaargdplggfqvtpegyahlthqlmslaagrvlii
    leggynltsisesmsmctsmllgdsppsldtplktsatvsinnvlrahapfwsslr