PDB entry 6mqn

View 6mqn on RCSB PDB site
Description: Crystal structure of KRAS V14I-GDP demonstrating disorder switch 1 conformation - Form 2
Class: hydrolase
Keywords: gtpase kras hydrolysis, hydrolase
Deposited on 2018-10-10, released 2019-07-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-02, with a file datestamp of 2019-09-27.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (0-End)
      • engineered mutation (13)
    Domains in SCOPe 2.08: d6mqna_
  • Chain 'B':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (0-168)
      • engineered mutation (13)
    Domains in SCOPe 2.08: d6mqnb_
  • Chain 'C':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (0-168)
      • engineered mutation (13)
    Domains in SCOPe 2.08: d6mqnc_
  • Heterogens: GDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6mqnA (A:)
mteyklvvvgaggigksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdl
psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >6mqnA (A:)
mteyklvvvgaggigksaltiqliqnhfvedsyrkqvvidgetclldildtagqeeysam
rdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrtvdt
kqaqdlarsygipfietsaktrqgvddafytlvreirkhke

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6mqnB (B:)
mteyklvvvgaggigksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdl
psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >6mqnB (B:)
mteyklvvvgaggigksaltiqliqnhfviedsyrkqvvidgetclldildtsamrdqym
rtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrtvdtkqaqd
larsygipfietsaktrqgvddafytlvreirkhkek

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6mqnC (C:)
mteyklvvvgaggigksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdl
psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >6mqnC (C:)
mteyklvvvgaggigksaltiqliqnhfvdyrkqvvidgetclldildtsamrdqymrtg
egflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrtvdtkqaqdlar
sygipfietsaktrqgvddafytlvreirkhkek