PDB entry 6mh2

View 6mh2 on RCSB PDB site
Description: Structure of Herceptin Fab without antigen
Class: immune system
Keywords: Herceptin, antibody, Fab fragment, IMMUNE SYSTEM
Deposited on 2018-09-17, released 2019-05-29
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-05-29, with a file datestamp of 2019-05-24.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Herceptin Fab arm light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MH2 (0-103)
    • Uniprot Q7Z3Y4 (104-213)
    Domains in SCOPe 2.07: d6mh2a1, d6mh2a2
  • Chain 'B':
    Compound: Herceptin Fab arm heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MH2 (0-End)
  • Chain 'C':
    Compound: Herceptin Fab arm light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MH2 (0-103)
    • Uniprot Q7Z3Y4 (104-213)
    Domains in SCOPe 2.07: d6mh2c1, d6mh2c2
  • Chain 'D':
    Compound: Herceptin Fab arm heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MH2 (0-End)

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6mh2A (A:)
    diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysasflysgvps
    rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6mh2C (C:)
    diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysasflysgvps
    rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >6mh2C (C:)
    diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysasflysgvps
    rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikrtvaapsvfifpp
    asvvcllnnfypreakvqwgnsqesvteqdskdstyslsstltlskadyekhkvyacevt
    hqglsspvtksfnrgec
    

  • Chain 'D':
    No sequence available.