PDB entry 6mda

View 6mda on RCSB PDB site
Description: Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyridine 4
Class: hydrolase/hydrolase inhibitor
Keywords: shp2, ptpn11, protein tyrosine phosphatase, phosphatase, allosteric inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase
Deposited on 2018-09-04, released 2019-02-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-02-13, with a file datestamp of 2019-02-08.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6mdaa1, d6mdaa2, d6mdaa3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6mdab1, d6mdab2, d6mdab3
  • Heterogens: JED, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6mdaA (A:)
    smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
    gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
    keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
    dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
    tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
    pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
    vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
    frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
    rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

    Sequence, based on observed residues (ATOM records): (download)
    >6mdaA (A:)
    rrwfhpnitgveaenllltrgvdgsflarpsnpgdftlsvrrngavthikiqntgdyydl
    yggekfatlaelvqyymehielkyplncadptserwfhghlsgkeaeklltekgkhgsfl
    vrepgdfvlsvrtgdskvthvmircqelkydvgggerfdsltdlvehykknpmvetlgtv
    lqlkqplnttrinaaeiesrvrelsklqgfweefetlqqqeckllysrkegqrqenknkn
    ryknilpfdhtrvvlhsdyinaniimpksyiatqgclqntvndfwrmvfqensrvivmtt
    kevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwq
    yhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilid
    iirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6mdaB (B:)
    smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
    gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
    keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
    dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
    tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
    pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
    vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
    frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
    rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

    Sequence, based on observed residues (ATOM records): (download)
    >6mdaB (B:)
    rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
    dlyggekfatlaelvqyymeqlkielkyplncadptserwfhghlsgkeaeklltekgkh
    gsflvrepgdfvlsvrtskvthvmircqelkydvgggerfdsltdlvehykknpmvetlg
    tvlqlkqplnttrinaaeiesrvrelskqgfweefetlqqqeckllysrkegqrqenknk
    nryknilpfdhtrvvlhvsdyinaniimpksyiatqgclqntvndfwrmvfqensrvivm
    ttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertv
    wqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividil
    idiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl