PDB entry 6md7

View 6md7 on RCSB PDB site
Description: Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrimidinone 7
Class: hydrolase/hydrolase inhibitor
Keywords: shp2, ptpn11, protein tyrosine phosphatase, phosphatase, allosteric inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase
Deposited on 2018-09-04, released 2019-02-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-09-25, with a file datestamp of 2019-09-20.
Experiment type: XRAY
Resolution: 1.96 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6md7a1, d6md7a2, d6md7a3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6md7b1, d6md7b2, d6md7b3
  • Heterogens: JE1, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6md7A (A:)
smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >6md7A (A:)
srrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdy
ydlyggekfatlaelvqyymehhgqlkengdvielkyplncadptserwfhghlsgkeae
klltekgkhgsflvresqshpgdfvlsvrtgdndgkskvthvmircqelkydvgggerfd
sltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklqgfweefetlqq
qeckllysrkegqrqenknknryknilpfdhtrvvlhdgdppvsdyinaniimpeksyia
tqgclqntvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvk
esaahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesi
mdagpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqtea
qyrfiymavqhyietl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6md7B (B:)
smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >6md7B (B:)
rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
dlyggekfatlaelvqyymehhgqlkengdvielkyplncadptserwfhghlsgkeaek
lltekgkhgsflvresqshpgdfvlsvrtndgkskvthvmircqelkydvgggerfdslt
dlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelskqgfweefetlqqqeck
llysrkegqrqenknknryknilpfdhtrvvlhvsdyinaniimpepkksyiatqgclqn
tvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdy
tlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvv
vhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiym
avqhyietl