PDB entry 6m6x

View 6m6x on RCSB PDB site
Description: Oridonin in complex with CRM1#-Ran-RanBP1
Class: transport protein
Keywords: Active Ran, Complex, TRANSPORT PROTEIN, inhibitor
Deposited on 2020-03-16, released 2021-03-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-09, with a file datestamp of 2021-06-04.
Experiment type: XRAY
Resolution: 2.88 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Gene: RAN, ARA24, OK/SW-cl.81
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62826 (Start-215)
      • engineered mutation (68)
      • engineered mutation (181)
    Domains in SCOPe 2.08: d6m6xa_
  • Chain 'B':
    Compound: Ran-specific GTPase-activating protein 1
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6m6xb_
  • Chain 'C':
    Compound: Exportin-1
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: CRM1, KAP124, XPO1, YGR218W, G8514
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30822 (3-End)
      • expression tag (1-2)
      • engineered mutation (29)
      • engineered mutation (51)
      • engineered mutation (466)
      • engineered mutation (481)
      • engineered mutation (483-485)
      • engineered mutation (497)
      • engineered mutation (505)
      • engineered mutation (685)
      • engineered mutation (966)
  • Heterogens: ODN, MG, EDO, GTP, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6m6xA (A:)
maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
fnvwdtaglekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
aaappevvmdpalaaqyehdlevaqttalpdedddl

    Sequence, based on observed residues (ATOM records): (download) 
    >6m6xA (A:)
qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
glekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampaaappev
vmdpalaaqyehdlevaqttalpdedddl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6m6xB (B:)
dihfepvvhlekvdvktmeedeevlykvraklfrfdadakewkergtgdckflknkktnk
vrilmrrdktlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgsk
enadkfkeefekaqeinkka

    Sequence, based on observed residues (ATOM records): (download) 
    >6m6xB (B:)
tmeedeevlykvraklfrfdadakewkergtgdckflknkktnkvrilmrrdktlkican
hiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgskenadkfkeefekaqei
nkk

  • Chain 'C':
    No sequence available.