PDB entry 6kyk

View 6kyk on RCSB PDB site
Description: Crystal structure of Shank3 NTD-ANK mutant in complex with Rap1
Class: structural protein/signaling protein
Keywords: Shank3, GTPase, synaptic scaffold protein, STRUCTURAL PROTEIN-SIGNALING PROTEIN complex
Deposited on 2019-09-19, released 2019-12-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-18, with a file datestamp of 2020-03-13.
Experiment type: XRAY
Resolution: 2.82 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: SH3 and multiple ankyrin repeat domains protein 3
    Species: Mus musculus [TaxId:10090]
    Gene: Shank3, Kiaa1650, Prosap2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4ACU6
      • engineered mutation (236)
      • engineered mutation (309)
  • Chain 'B':
    Compound: SH3 and multiple ankyrin repeat domains protein 3
    Species: Mus musculus [TaxId:10090]
    Gene: Shank3, Kiaa1650, Prosap2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4ACU6
      • engineered mutation (236)
      • engineered mutation (309)
  • Chain 'C':
    Compound: Ras-related protein Rap-1b
    Species: Homo sapiens [TaxId:9606]
    Gene: RAP1B, OK/SW-cl.11
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61224 (3-169)
      • expression tag (1-2)
    Domains in SCOPe 2.08: d6kykc1, d6kykc2
  • Chain 'D':
    Compound: Ras-related protein Rap-1b
    Species: Homo sapiens [TaxId:9606]
    Gene: RAP1B, OK/SW-cl.11
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61224 (3-169)
      • expression tag (2)
    Domains in SCOPe 2.08: d6kykd1, d6kykd2
  • Chain 'E':
    Compound: Ras-related protein Rap-1b
    Species: Homo sapiens [TaxId:9606]
    Gene: RAP1B, OK/SW-cl.11
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61224 (3-169)
      • expression tag (1-2)
    Domains in SCOPe 2.08: d6kyke1, d6kyke2
  • Chain 'F':
    Compound: Ras-related protein Rap-1b
    Species: Homo sapiens [TaxId:9606]
    Gene: RAP1B, OK/SW-cl.11
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61224 (3-169)
      • expression tag (2)
    Domains in SCOPe 2.08: d6kykf1, d6kykf2
  • Heterogens: GNP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6kykC (C:)
gphmreyklvvlgsggvgksaltvqfvqgifvekydptiedsyrkqvevdaqqcmleild
tagteqftamrdlymkngqgfalvysitaqstfndlqdlreqilrvkdtddvpmilvgnk
cdledervvgkeqgqnlarqwnncaflessakskinvneifydlvrqinr

    Sequence, based on observed residues (ATOM records): (download) 
    >6kykC (C:)
phmreyklvvlgsggvgksaltvqfvqgifvekydptiedsyrkqvevdaqqcmleildt
agteqftamrdlymkngqgfalvysitaqstfndlqdlreqilrvkdtddvpmilvgnkc
dledervvgkeqgqnlarqwnncaflessakskinvneifydlvrqinr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6kykD (D:)
gphmreyklvvlgsggvgksaltvqfvqgifvekydptiedsyrkqvevdaqqcmleild
tagteqftamrdlymkngqgfalvysitaqstfndlqdlreqilrvkdtddvpmilvgnk
cdledervvgkeqgqnlarqwnncaflessakskinvneifydlvrqinr

    Sequence, based on observed residues (ATOM records): (download) 
    >6kykD (D:)
hmreyklvvlgsggvgksaltvqfvqgifvekydptiedsyrkqvevdaqqcmleildta
gteqftamrdlymkngqgfalvysitaqstfndlqdlreqilrvkdtddvpmilvgnkcd
ledervvgkeqgqnlarqwnncaflessakskinvneifydlvrqinr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6kykE (E:)
gphmreyklvvlgsggvgksaltvqfvqgifvekydptiedsyrkqvevdaqqcmleild
tagteqftamrdlymkngqgfalvysitaqstfndlqdlreqilrvkdtddvpmilvgnk
cdledervvgkeqgqnlarqwnncaflessakskinvneifydlvrqinr

    Sequence, based on observed residues (ATOM records): (download) 
    >6kykE (E:)
phmreyklvvlgsggvgksaltvqfvqgifvekydptiedsyrkqvevdaqqcmleildt
agteqftamrdlymkngqgfalvysitaqstfndlqdlreqilrvkdtddvpmilvgnkc
dledervvgkeqgqnlarqwnncaflessakskinvneifydlvrqinr

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6kykF (F:)
gphmreyklvvlgsggvgksaltvqfvqgifvekydptiedsyrkqvevdaqqcmleild
tagteqftamrdlymkngqgfalvysitaqstfndlqdlreqilrvkdtddvpmilvgnk
cdledervvgkeqgqnlarqwnncaflessakskinvneifydlvrqinr

    Sequence, based on observed residues (ATOM records): (download) 
    >6kykF (F:)
hmreyklvvlgsggvgksaltvqfvqgifvekydptiedsyrkqvevdaqqcmleildta
gteqftamrdlymkngqgfalvysitaqstfndlqdlreqilrvkdtddvpmilvgnkcd
ledervvgkeqgqnlarqwnncaflessakskinvneifydlvrqinr