PDB entry 6i0z

View 6i0z on RCSB PDB site
Description: crystal structure of fascin in complex with compound 1
Class: structural protein
Keywords: actin bundling, small molecule inhibition, STRUCTURAL PROTEIN
Deposited on 2018-10-27, released 2019-02-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-02-27, with a file datestamp of 2019-02-22.
Experiment type: XRAY
Resolution: 1.77 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fascin
    Species: Homo sapiens [TaxId:9606]
    Gene: FSCN1, FAN1, HSN, SNL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6i0za1, d6i0za2, d6i0za3, d6i0za4
  • Chain 'B':
    Compound: fascin
    Species: Homo sapiens [TaxId:9606]
    Gene: FSCN1, FAN1, HSN, SNL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6i0zb1, d6i0zb2, d6i0zb3, d6i0zb4
  • Heterogens: GZQ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6i0zA (A:)
    mtangtaeavqiqfglincgnkyltaeafgfkvnasasslkkkqiwtleqppdeagsaav
    clrshlgrylaadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrls
    cfaqtvspaekwsvhiamhpqvniysvtrkryahlsarpadeiavdrdvpwgvdslitla
    fqdqrysvqtadhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtl
    kagkatkvgkdelfaleqscaqvvlqaanernvstrqgmdlsanqdeetdqetfqleidr
    dtkkcafrthtgkywtltatggvqstassknascyfdiewrdrritlrasngkfvtskkn
    gqlaasvetagdselflmklinrpiivfrgehgfigcrkvtgtldanrssydvfqlefnd
    gaynikdstgkywtvgsdsavtssgdtpvdfffefcdynkvaikvggrylkgdhagvlka
    saetvdpaslwey
    

    Sequence, based on observed residues (ATOM records): (download)
    >6i0zA (A:)
    taeavqiqfglincgnkyltaeafgfkvnasasslkkkqiwtleqppdeagsaavclrsh
    lgrylaadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrlscfaqt
    vspaekwsvhiamhpqvniysvtrkryahlsarpadeiavdrdvpwgvdslitlafqdqr
    ysvqtadhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtlkagka
    tkvgkdelfaleqscaqvvlqaanernvstdlsanqdeetdqetfqleidrdtkkcafrt
    htgkywtltatggvqstassknascyfdiewrdrritlrasngkfvtskkngqlaasvet
    agdselflmklinrpiivfrgehgfigcrkvtgtldanrssydvfqlefndgaynikdst
    gkywtvgsdsavtssgdtpvdfffefcdynkvaikvggrylkgdhagvlkasaetvdpas
    lwey
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6i0zB (B:)
    mtangtaeavqiqfglincgnkyltaeafgfkvnasasslkkkqiwtleqppdeagsaav
    clrshlgrylaadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrls
    cfaqtvspaekwsvhiamhpqvniysvtrkryahlsarpadeiavdrdvpwgvdslitla
    fqdqrysvqtadhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtl
    kagkatkvgkdelfaleqscaqvvlqaanernvstrqgmdlsanqdeetdqetfqleidr
    dtkkcafrthtgkywtltatggvqstassknascyfdiewrdrritlrasngkfvtskkn
    gqlaasvetagdselflmklinrpiivfrgehgfigcrkvtgtldanrssydvfqlefnd
    gaynikdstgkywtvgsdsavtssgdtpvdfffefcdynkvaikvggrylkgdhagvlka
    saetvdpaslwey
    

    Sequence, based on observed residues (ATOM records): (download)
    >6i0zB (B:)
    taeavqiqfglincgnkyltaeafgfkvnasasslkkkqiwtleqpsaavclrshlgryl
    aadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrlscfaqtvspae
    kwsvhiamhpqvniysvtrkryahlsarpadeiavdrdvpwgvdslitlafqdqrysvqt
    adhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtlkagkatkvgk
    delfaleqscaqvvlqaanernvstrqgmdlsanqdeetdqetfqleidrdtkkcafrth
    tgkywtltatggvqstassknascyfdiewrdrritlrasngkfvtskkngqlaasveta
    gdselflmklinrpiivfrgehgfigcrkvtgtldanrssydvfqlefndgaynikdstg
    kywtvgsdsavtssgdtpvdfffefcdynkvaikvggrylkgdhagvlkasaetvdpasl
    wey