PDB entry 6hm7

View 6hm7 on RCSB PDB site
Description: crystal structure of spleen tyrosine kinase (syk) in complex with a 2-(phenoxymethyl)pyridine inhibitor
Class: transferase
Keywords: SK363, SYK, non-receptor tyrosine kinase, spleen tyrosine kinase, TRANSFERASE
Deposited on 2018-09-12, released 2018-10-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-10-10, with a file datestamp of 2018-10-05.
Experiment type: XRAY
Resolution: 1.64 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase SYK
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6hm7a_
  • Heterogens: GDH, BR, GOL, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6hm7A (A:)
    pkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdella
    eanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvs
    mgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwy
    apecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpr
    emydlmnlcwtydvenrpgfaavelrlrnyyydvvn
    

    Sequence, based on observed residues (ATOM records): (download)
    >6hm7A (A:)
    vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdellaean
    vmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgm
    kyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqtwpvkwyapecin
    yykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlm
    nlcwtydvenrpgfaavelrlrnyyydv