PDB entry 6h7j

View 6h7j on RCSB PDB site
Description: ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY Nb80
Class: immune system
Keywords: Beta1 Adrenoceptor, Activated, Agonist, Nanobody, Immune system
Deposited on 2018-07-31, released 2018-10-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-06-05, with a file datestamp of 2019-05-30.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: beta-1 adrenergic receptor
    Species: Meleagris gallopavo [TaxId:9103]
    Gene: ADRB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07700 (5-End)
      • expression tag (1-4)
      • engineered mutation (29)
      • engineered mutation (51)
      • engineered mutation (77)
      • conflict (217)
      • engineered mutation (260)
      • engineered mutation (271)
  • Chain 'B':
    Compound: beta-1 adrenergic receptor
    Species: Meleagris gallopavo [TaxId:9103]
    Gene: ADRB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07700 (5-End)
      • expression tag (0-4)
      • engineered mutation (29)
      • engineered mutation (51)
      • engineered mutation (77)
      • conflict (217)
      • engineered mutation (260)
      • engineered mutation (271)
      • engineered mutation (291)
  • Chain 'C':
    Compound: Camelid antibody fragment Nb80
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6H7J (Start-120)
    Domains in SCOPe 2.08: d6h7jc1, d6h7jc2
  • Chain 'D':
    Compound: Camelid antibody fragment Nb80
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6H7J (Start-120)
    Domains in SCOPe 2.08: d6h7jd1, d6h7jd2
  • Chain 'E':
    Compound: Thioredoxin 1
    Species: Escherichia coli (strain K12) [TaxId:83333]
    Gene: trxA, fipA, tsnC, b3781, JW5856
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AA25 (Start-107)
      • engineered mutation (31)
      • engineered mutation (34)
    Domains in SCOPe 2.08: d6h7je_
  • Chain 'F':
    Compound: Thioredoxin 1
    Species: Escherichia coli (strain K12) [TaxId:83333]
    Gene: trxA, fipA, tsnC, b3781, JW5856
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AA25
      • engineered mutation (31)
      • engineered mutation (34)
    Domains in SCOPe 2.08: d6h7jf_
  • Heterogens: 5FW, NA, 2CV, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6h7jC (C:)
sqvqlqesggglvqaggslrlscaasgsifsintmgwyrqapgkqrelvaaihsggstny
ansvkgrftisrdnaantvylqmnslkpedtavyycnvkdygavlyeydywgqgtqvtvs
s

    Sequence, based on observed residues (ATOM records): (download) 
    >6h7jC (C:)
vqlqesggglvqaggslrlscaasgsifsintmgwyrqapgkqrelvaaihsggstnyan
svkgrftisrdnaantvylqmnslkpedtavyycnvkdygavlyeydywgqgtqvtvss

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6h7jD (D:)
sqvqlqesggglvqaggslrlscaasgsifsintmgwyrqapgkqrelvaaihsggstny
ansvkgrftisrdnaantvylqmnslkpedtavyycnvkdygavlyeydywgqgtqvtvs
s

    Sequence, based on observed residues (ATOM records): (download) 
    >6h7jD (D:)
qvqlqesggglvqaggslrlscaasgsifsintmgwyrqapgkqrelvaaihsggstnya
nsvkgrftisrdnaantvylqmnslkpedtavyycnvkdygavlyeydywgqgtqvtvss

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6h7jE (E:)
sdkiihltddsfdtdvlkadgailvdfwaewsgpskmiapildeiadeyqgkltvaklni
dqnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlae

    Sequence, based on observed residues (ATOM records): (download) 
    >6h7jE (E:)
kiihltddsfdtdvlkadgailvdfwaewsgpskmiapildeiadeyqgkltvaklnidq
npgtapkygirgiptlllfkngevaatkvgalskgqlkefldanla

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6h7jF (F:)
sdkiihltddsfdtdvlkadgailvdfwaewsgpskmiapildeiadeyqgkltvaklni
dqnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlae

    Sequence, based on observed residues (ATOM records): (download) 
    >6h7jF (F:)
dkiihltddsfdtdvlkadgailvdfwaewsgpskmiapildeiadeyqgkltvaklnid
qnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanl