PDB entry 6h5w

View 6h5w on RCSB PDB site
Description: Crystal structure of human Angiotensin-1 converting enzyme C-domain in complex with Omapatrilat.
Class: hydrolase
Keywords: Angiotensin-1 converting enzyme, ACE inhibitor, Omapatrilat, Vasopeptidase inhibitor, HYDROLASE
Deposited on 2018-07-25, released 2018-11-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 1.37 Å
R-factor: N/A
AEROSPACI score: 0.65 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: angiotensin-converting enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: ACE, DCP, DCP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12821
      • engineered mutation (27)
      • engineered mutation (53)
      • engineered mutation (118)
      • engineered mutation (300)
      • engineered mutation (549)
    Domains in SCOPe 2.08: d6h5wa_
  • Heterogens: FT8, ZN, CL, IMD, BO3, P6G, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6h5wA (A:)
lvtdeaeaskfveeydrtsqvvwneyaganwnyntnittetskillqknmqiaqhtlkyg
tqarkfdvnqlqnttikriikkvqdleraalpaqeleeynkilldmettysvatvchpqg
sclqlepdltnvmatsrkyedllwawegwrdkagrailqfypkyvelinqaarlngyvda
gdswrsmyetpsleqdlerlfqelqplylnlhayvrralhrhygaqhinlegpipahllg
nmwaqtwsniydlvvpfpsapsmdtteamlkqgwtprrmfkeaddfftslgllpvppefw
qksmlekptdgrevvchasawdfyngkdfrikqcttvnledlvvahhemghiqyfmqykd
lpvalreganpgfheaigdvlalsvstpkhlhslnllsseggsdehdinflmkmaldkia
fipfsylvdqwrwrvfdgsitkenynqewwslrlkyqglcppvprtqgdfdpgakfhips
svpyiryfvsfiiqfqfhealcqaaghtgplhkcdiyqskeagqrlatamklgfsrpwpe
amqlitgqpqmsasamlsyfkplldwlrtenelhgeklgwpqynwtpnsar

    Sequence, based on observed residues (ATOM records): (download) 
    >6h5wA (A:)
deaeaskfveeydrtsqvvwneyaganwnyntnittetskillqknmqiaqhtlkygtqa
rkfdvnqlqnttikriikkvqdleraalpaqeleeynkilldmettysvatvchpqgscl
qlepdltnvmatsrkyedllwawegwrdkagrailqfypkyvelinqaarlngyvdagds
wrsmyetpsleqdlerlfqelqplylnlhayvrralhrhygaqhinlegpipahllgnmw
aqtwsniydlvvpfpsapsmdtteamlkqgwtprrmfkeaddfftslgllpvppefwqks
mlekptdgrevvchasawdfyngkdfrikqcttvnledlvvahhemghiqyfmqykdlpv
alreganpgfheaigdvlalsvstpkhlhslnllsseggsdehdinflmkmaldkiafip
fsylvdqwrwrvfdgsitkenynqewwslrlkyqglcppvprtqgdfdpgakfhipssvp
yiryfvsfiiqfqfhealcqaaghtgplhkcdiyqskeagqrlatamklgfsrpwpeamq
litgqpqmsasamlsyfkplldwlrtenelhgeklgwpqynwtpns