PDB entry 6gwq
View 6gwq on RCSB PDB site
Description: Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with an Inhibitory Nanobody (VHH-2g-42)
Class: hydrolase
Keywords: plasminogen activator inhibitor-1, PAI-1, PAI-1-stab, serpin, protease inhibitor, serine protease inhibitor, nanobody, antibody fragment, protein complex, hydrolase
Deposited on
2018-06-25, released
2020-01-01
The last revision prior to the SCOPe 2.08 freeze date was dated
2021-02-10, with a file datestamp of
2021-02-05.
Experiment type: XRAY
Resolution: 2.32 Å
R-factor: N/A
AEROSPACI score: 0.32
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: plasminogen activator inhibitor-1
Species: Homo sapiens [TaxId:9606]
Gene: SERPINE1
Database cross-references and differences (RAF-indexed):
- Uniprot P05121 (0-378)
- engineered mutation (149)
- engineered mutation (153)
- engineered mutation (300)
- engineered mutation (318)
- engineered mutation (353)
Domains in SCOPe 2.08: d6gwqa_ - Chain 'B':
Compound: VHH-2g-42
Species: VICUGNA PACOS [TaxId:30538]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6gwqb_ - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6gwqA (A:)
vhhppsyvahlasdfgvrvfqqvaqaskdrnvvfspygvasvlamlqlttggetqqqiqa
amgfkiddkgmapalrhlykelmgpwnkdeisttdaifvqrdlklvqgfmphffrlfrst
vkqvdfseverarfiindwvkthtkgmishllgtgavdqltrlvlvnalyfngqwktpfp
dssthrrlfhksdgstvsvpmmaqtnkfnytefttpdghyydilelpyhgdtlsmfiaap
yekevplsaltnilsaqlishwkgnmtrlprllvlpkfsletevdlrkplenlgmtdmfr
pfqadftslsdqeplhvalalqkvkievnesgtvassstavivsarmapeeiiidrpflf
vvrhnptgtvlfmgqvmep
Sequence, based on observed residues (ATOM records): (download)
>6gwqA (A:)
vhhppsyvahlasdfgvrvfqqvaqaskdrnvvfspygvasvlamlqlttggetqqqiqa
amgfkiddkgmapalrhlykelmgpwdeisttdaifvqrdlklvqgfmphffrlfrstvk
qvdfseverarfiindwvkthtkgmishllgtgavdqltrlvlvnalyfngqwktpfpds
sthrrlfhksdgstvsvpmmaqtnkfnytefttpdghyydilelpyhgdtlsmfiaapye
kevplsaltnilsaqlishwkgnmtrlprllvlpkfsletevdlrkplenlgmtdmfrpf
qadftslsdqeplhvalalqkvkievnespeeiiidrpflfvvrhnptgtvlfmgqvmep
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6gwqB (B:)
qvqlvesggglvqpggrlrlscaasgftfrtyamqwyrqspgterelvaaisniggvtdy
gdsvkgrftisrdnakttvylemnslkpedtatyycsavrlpqrywgrgtqvtvss
Sequence, based on observed residues (ATOM records): (download)
>6gwqB (B:)
qvqlvesggglvqpggrlrlscaasgftfrtyamqwyrqspgterelvaaisniggvtdy
gdsvkgrftisrdnakttvylemnslkpedtatyycsavrlpqrywgrgtqvtvs