PDB entry 6gva
View 6gva on RCSB PDB site
Description: CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR4455
Class: cell cycle
Keywords: cyclin-dependent kinase, pyrazolo[4, 3-d]pyrimidine, CELL CYCLE
Deposited on
2018-06-20, released
2019-05-01
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-05-22, with a file datestamp of
2019-05-17.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.28
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cyclin-dependent kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: CDK2, CDKN2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6gvaa_ - Chain 'B':
Compound: Cyclin-A2
Species: Homo sapiens [TaxId:9606]
Gene: CCNA2, CCN1, CCNA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6gvab1, d6gvab2 - Heterogens: FCQ, EDO, CL, BR, PG4, SGM, PGE, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6gvaA (A:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
Sequence, based on observed residues (ATOM records): (download)
>6gvaA (A:)
menfqkvekigegtygvvykarnkltgevvalkkirldtegvpstaireisllkelnhpn
ivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshr
vlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyyst
avdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpk
warqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvt
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>6gvaB (B:)
vpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhl
avnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrm
ehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsv
iagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyk
nskyhgvsllnppetlnl