PDB entry 6gfi

View 6gfi on RCSB PDB site
Description: Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V
Class: protein binding
Keywords: protein protein interactions, serine proteases, amyloid protein precursor inhibitor, protein binding
Deposited on 2018-04-30, released 2018-09-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-10-10, with a file datestamp of 2018-10-05.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: PRSS3 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: PRSS3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8N2U3 (0-223)
      • conflict (176)
    Domains in SCOPe 2.08: d6gfia_
  • Chain 'B':
    Compound: PRSS3 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: PRSS3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8N2U3 (0-223)
      • conflict (176)
    Domains in SCOPe 2.08: d6gfib_
  • Chain 'C':
    Compound: Amyloid-beta A4 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: APP, A4, AD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05067 (17-End)
      • expression tag (11-16)
      • engineered mutation (20)
      • conflict (26-27)
      • conflict (43)
    Domains in SCOPe 2.08: d6gfic1, d6gfic2
  • Chain 'E':
    Compound: Amyloid-beta A4 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: APP, A4, AD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05067 (17-End)
      • expression tag (11-16)
      • engineered mutation (20)
      • conflict (26-27)
      • conflict (43)
    Domains in SCOPe 2.08: d6gfie1, d6gfie2
  • Heterogens: EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6gfiA (A:)
ivggytceenslpyqvslnsgshfcggsliseqwvvsaahcyktriqvrlgehnikvleg
neqfinaakiirhpkynrdtldndimliklsspavinarvstislptappaagteclisg
wgntlsfgadypdelkcldapvltqaeckasypgkitnsmfcvgfleggkdscqrdaggp
vvcngqlqgvvswghgcawknrpgvytkvynyvdwikdtiaans

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6gfiB (B:)
ivggytceenslpyqvslnsgshfcggsliseqwvvsaahcyktriqvrlgehnikvleg
neqfinaakiirhpkynrdtldndimliklsspavinarvstislptappaagteclisg
wgntlsfgadypdelkcldapvltqaeckasypgkitnsmfcvgfleggkdscqrdaggp
vvcngqlqgvvswghgcawknrpgvytkvynyvdwikdtiaans

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6gfiC (C:)
yvdykddddkevevcseqaevgpcrarfsrwyfdvtegkcapfvyggcggnrnnfdteey
cmavcgsaiprhhhhhhaaan

    Sequence, based on observed residues (ATOM records): (download) 
    >6gfiC (C:)
vevcseqaevgpcrarfsrwyfdvtegkcapfvyggcggnrnnfdteeycmavcgs

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6gfiE (E:)
yvdykddddkevevcseqaevgpcrarfsrwyfdvtegkcapfvyggcggnrnnfdteey
cmavcgsaiprhhhhhhaaan

    Sequence, based on observed residues (ATOM records): (download) 
    >6gfiE (E:)
vevcseqaevgpcrarfsrwyfdvtegkcapfvyggcggnrnnfdteeycmavcgs