PDB entry 6fgb

View 6fgb on RCSB PDB site
Description: Human FcRn extra-cellular domain complexed with Fab fragment of Rozanolixizumab
Class: immune system
Keywords: FcRn, rozanolixizumab, ECD, Fab, immune system
Deposited on 2018-01-10, released 2018-08-29
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-08-29, with a file datestamp of 2018-08-24.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6fgba1, d6fgba2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6fgbb_
  • Chain 'H':
    Compound: 1519.g57- Heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6FGB
  • Chain 'L':
    Compound: 1519.g57- Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6FGB (0-218)
    Domains in SCOPe 2.07: d6fgbl1, d6fgbl2
  • Heterogens: CL, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6fgbA (A:)
    aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
    wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
    dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
    smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
    tvksgdehhyccivqhaglaqplrvelespakssvlvvgivigvllltaaavggallwrr
    mrsglpapwislrgddtgvllptpgeaqdadlkdvnvipata
    

    Sequence, based on observed residues (ATOM records): (download)
    >6fgbA (A:)
    hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywek
    ettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlk
    qgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmr
    lkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvk
    sgdehhyccivqhaglaqplrvele
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6fgbB (B:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6fgbL (L:)
    diqmtqspsslsasvgdrvtitckssqslvgasgktylywlfqkpgkapkrliylvstld
    sgipsrfsgsgsgteftltisslqpedfatyyclqgthfphtfgqgtkleikrtvaapsv
    fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
    sstltlskadyekhkvyacevthqglsspvtksfnrgec