PDB entry 6fgb

View 6fgb on RCSB PDB site
Description: Human FcRn extra-cellular domain complexed with Fab fragment of Rozanolixizumab
Class: immune system
Keywords: FcRn, rozanolixizumab, ECD, Fab, immune system
Deposited on 2018-01-10, released 2018-08-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-10-03, with a file datestamp of 2018-09-28.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6fgba1, d6fgba2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6fgbb_
  • Chain 'H':
    Compound: 1519.g57- Heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6FGB
    Domains in SCOPe 2.08: d6fgbh_
  • Chain 'L':
    Compound: 1519.g57- Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6FGB (0-218)
    Domains in SCOPe 2.08: d6fgbl1, d6fgbl2
  • Heterogens: CL, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6fgbA (A:)
aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
tvksgdehhyccivqhaglaqplrvelespakssvlvvgivigvllltaaavggallwrr
mrsglpapwislrgddtgvllptpgeaqdadlkdvnvipata

    Sequence, based on observed residues (ATOM records): (download) 
    >6fgbA (A:)
hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywek
ettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlk
qgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmr
lkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvk
sgdehhyccivqhaglaqplrvele

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fgbB (B:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6fgbH (H:)
evplvesggglvqpggslrlscavsgftfsnygmvwvrqapgkglewvayidsdgdntyy
rdsvkgrftisrdnaksslylqmnslraedtavyycttgivrpflywgqgtlvtvssast
kgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcaa

    Sequence, based on observed residues (ATOM records): (download) 
    >6fgbH (H:)
vplvesggglvqpggslrlscavsgftfsnygmvwvrqapgkglewvayidsdgdntyyr
dsvkgrftisrdnaksslylqmnslraedtavyycttgivrpflywgqgtlvtvssastk
gpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fgbL (L:)
diqmtqspsslsasvgdrvtitckssqslvgasgktylywlfqkpgkapkrliylvstld
sgipsrfsgsgsgteftltisslqpedfatyyclqgthfphtfgqgtkleikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrgec