PDB entry 6e45

View 6e45 on RCSB PDB site
Description: CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) free enzyme in the ferrous state
Class: oxidoreductase
Keywords: IDO1, free enzyme, ferrous state, OXIDOREDUCTASE
Deposited on 2018-07-16, released 2018-11-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-11-14, with a file datestamp of 2018-11-09.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Indoleamine 2,3-dioxygenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IDO1, IDO, INDO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14902 (16-End)
      • expression tag (15)
      • engineered mutation (117-118)
    Domains in SCOPe 2.08: d6e45a1, d6e45a2
  • Chain 'B':
    Compound: Indoleamine 2,3-dioxygenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IDO1, IDO, INDO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14902 (16-End)
      • expression tag (15)
      • engineered mutation (117-118)
    Domains in SCOPe 2.08: d6e45b1, d6e45b2
  • Chain 'C':
    Compound: Indoleamine 2,3-dioxygenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IDO1, IDO, INDO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14902 (16-End)
      • expression tag (15)
      • engineered mutation (117-118)
    Domains in SCOPe 2.08: d6e45c1, d6e45c2
  • Chain 'D':
    Compound: Indoleamine 2,3-dioxygenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IDO1, IDO, INDO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14902 (16-End)
      • expression tag (15)
      • engineered mutation (117-118)
    Domains in SCOPe 2.08: d6e45d1, d6e45d2
  • Heterogens: HEM, GOL, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6e45A (A:)
mgsshhhhhhssgsaayhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrer
veklnmlsidhltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlsaal
elppilvyadcvlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasai
kviptvfkamqmqerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwk
gnpqlsdglvyegfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrry
mppahrnflcslesnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipa
sqqpkenktsedpskleakgtggtdlmnflktvrstteksllkeg

    Sequence, based on observed residues (ATOM records): (download) 
    >6e45A (A:)
ayhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhltdh
ksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlsaalelppilvyadcvlan
wkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmqer
dtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyegfw
edpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcslesn
psvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqgtdlmnflktvrs
tteksllk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6e45B (B:)
mgsshhhhhhssgsaayhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrer
veklnmlsidhltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlsaal
elppilvyadcvlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasai
kviptvfkamqmqerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwk
gnpqlsdglvyegfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrry
mppahrnflcslesnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipa
sqqpkenktsedpskleakgtggtdlmnflktvrstteksllkeg

    Sequence, based on observed residues (ATOM records): (download) 
    >6e45B (B:)
ayhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhltdh
ksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlsaalelppilvyadcvlan
wkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmqer
dtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyegfw
edpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcslesn
psvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqakgtggtdlmnfl
ktvrstteksllk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6e45C (C:)
mgsshhhhhhssgsaayhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrer
veklnmlsidhltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlsaal
elppilvyadcvlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasai
kviptvfkamqmqerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwk
gnpqlsdglvyegfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrry
mppahrnflcslesnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipa
sqqpkenktsedpskleakgtggtdlmnflktvrstteksllkeg

    Sequence, based on observed residues (ATOM records): (download) 
    >6e45C (C:)
ayhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhltdh
ksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlsaalelppilvyadcvlan
wkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmqer
dtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyegfw
edpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcslesn
psvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqggtdlmnflktvr
stteksllke

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6e45D (D:)
mgsshhhhhhssgsaayhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrer
veklnmlsidhltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlsaal
elppilvyadcvlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasai
kviptvfkamqmqerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwk
gnpqlsdglvyegfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrry
mppahrnflcslesnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipa
sqqpkenktsedpskleakgtggtdlmnflktvrstteksllkeg

    Sequence, based on observed residues (ATOM records): (download) 
    >6e45D (D:)
ayhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhltdh
ksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlsaalelppilvyadcvlan
wkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmqer
dtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyegfw
edpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcslesn
psvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqggtdlmnflktvr
stteksllk