PDB entry 6dtp

View 6dtp on RCSB PDB site
Description: crystal structure of human 17beta-hydroxysteroid dehydrogenase type 1 complexed with em139
Class: OXIDOREDUCTASE/Inhibitor
Keywords: 17BETA-HSD1, OXIDOREDUCTASE, STEROID, inhibitor, OXIDOREDUCTASE-Inhibitor complex
Deposited on 2018-06-18, released 2018-09-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-09-12, with a file datestamp of 2018-09-07.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estradiol 17-beta-dehydrogenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD17B1, E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6dtpa_
  • Chain 'B':
    Compound: Estradiol 17-beta-dehydrogenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD17B1, E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6dtpb_
  • Heterogens: EM9, GOL, EDO, PGE, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6dtpA (A:)
martvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsl
etlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtv
rmlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvh
lsliecgpvhtafmekvlgspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaev
fltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfgdvpakaeagaeagg
gagpgaedeagrgavgdpelgdppaapq

    Sequence, based on observed residues (ATOM records): (download) 
    >6dtpA (A:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtagspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevfltalra
pkptlryftterflpllrmrlddpsgsnyvtamhrevfg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6dtpB (B:)
martvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsl
etlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtv
rmlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvh
lsliecgpvhtafmekvlgspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaev
fltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfgdvpakaeagaeagg
gagpgaedeagrgavgdpelgdppaapq

    Sequence, based on observed residues (ATOM records): (download) 
    >6dtpB (B:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtgspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevfltalrap
kptlryftterflpllrmrlddpsgsnyvtamhrevfg