PDB entry 6crf

View 6crf on RCSB PDB site
Description: Crystal Structure of Shp2 E76K GOF Mutant in the Open Conformation
Class: hydrolase
Keywords: SHP2, PTPN11, PROTEIN TYROSINE PHOSPHATASE, E76K, Gain of Function Mutant, Open Conformation, PHOSPHATASE, HYDROLASE
Deposited on 2018-03-17, released 2018-11-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-11-07, with a file datestamp of 2018-11-02.
Experiment type: XRAY
Resolution: 2.62 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124 (1-525)
      • expression tag (0)
      • engineered mutation (76)
    Domains in SCOPe 2.08: d6crfa1, d6crfa2, d6crfa3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124 (Start-525)
      • engineered mutation (76)
    Domains in SCOPe 2.08: d6crfb1, d6crfb2
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6crfA (A:)
gmtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaklvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >6crfA (A:)
gmtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaklvqyymehhgqlkgdvielkyplncadptserwfhghlsgkea
eklltekgkhgsflvredfvlsvrtkvthvmirckydvgggerfdsltdlvehykknpml
qlkqplnttrinaaeiesrvrelsklqgfweefetlqqqeckllysrkegqrqenknknr
yknilpfdhtrvvlhdgdpnepvsdyinaniimpksyiatqgclqntvndfwrmvfqens
rvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgn
tertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfi
vidilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6crfB (B:)
gmtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaklvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >6crfB (B:)
rrwfhpnitgveaenllltrdgsflarpnpgdftlsvrvthikiqntgdyydlyggekfa
tlaklvqyymehhgvielkyplncadptserwfhghlsgkeaeklltekgkhgsflvrsh
pgdfvlsvrtkvthvmirckydverfdsltdlvehykknpkqplnttrinaaeiesrvre
lsqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpnepvs
dyinaniimpksyiatqgclqntvndfwrmvfqensrvivmttkevergkskcvkywpde
yalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpgg
vldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdcdidvpkti
qmvrsqrsgmvqteaqyrfiymavqhyietl