PDB entry 6chd

View 6chd on RCSB PDB site
Description: Crystal Structure of Human Lysyl-tRNA Synthetase complexed with L-Lysylsulfamoyl Adenosine
Class: ligase,transferase
Keywords: ATP binding, aminoacylation, amino acid binding, ATP adenylyltransferase activity, tRNA binding, LIGASE, TRANSFERASE, Structure-guided Drug Discovery Consortium
Deposited on 2018-02-22, released 2018-03-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-03-07, with a file datestamp of 2018-03-02.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine--tRNA ligase
    Species: Homo sapiens [TaxId:9606]
    Gene: KARS, KIAA0070
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6chda1, d6chda2
  • Chain 'B':
    Compound: Lysine--tRNA ligase
    Species: Homo sapiens [TaxId:9606]
    Gene: KARS, KIAA0070
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6chdb1, d6chdb2
  • Heterogens: KAA, SO4, EDO, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6chdA (A:)
maavqaaevkvdgsepklsknelkrrlkaekkvaekeakqkelsekqlsqataaatnhtt
dngvgpeeesvdpnqyykirsqaihqlkvngedpyphkfhvdisltdfiqkyshlqpgdh
ltditlkvagrihakrasggklifydlrgegvklqvmansrnykseeefihinnklrrgd
iigvqgnpgktkkgelsiipyeitllspclhmlphlhfglkdketryrqryldlilndfv
rqkfiirskiityirsfldelgfleietpmmniipggavakpfityhneldmnlymriap
elyhkmlvvggidrvyeigrqfrnegidlthnpefttcefymayadyhdlmeitekmvsg
mvkhitgsykvtyhpdgpegqaydvdftppfrrinmveelekalgmklpetnlfeteetr
kilddicvakavecppprttarlldklvgeflevtcinptficdhpqimsplakwhrske
glterfelfvmkkeicnaytelndpmrqrqlfeeqakakaagddeamfidenfctaleyg
lpptagwgmgidrvamfltdsnnikevllfpamkpedkkenvattdtlesttvgtsv

    Sequence, based on observed residues (ATOM records): (download) 
    >6chdA (A:)
vdpnqyykirsqaihqlkvngedpyphkfhvdisltdfiqkyshlqpgdhltditlkvag
rihakrasggklifydlrgegvklqvmansrnykseeefihinnklrrgdiigvqgnpgk
tkkgelsiipyeitllspclhmlphlhfglkdketryrqryldlilndfvrqkfiirski
ityirsfldelgfleietpmmniipggavakpfityhneldmnlymriapelyhkmlvvg
gidrvyeigrqfrnegidlthnpefttcefymayadyhdlmeitekmvsgmvkhitgsyk
vtyhpdgpegqaydvdftppfrrinmveelekalgmklpetnlfeteetrkilddicvak
avecppprttarlldklvgeflevtcinptficdhpqimsplakwhrskeglterfelfv
mkkeicnaytelndpmrqrqlfeeqakakaagddeamfidenfctaleyglpptagwgmg
idrvamfltdsnnikevllfpamkpe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6chdB (B:)
maavqaaevkvdgsepklsknelkrrlkaekkvaekeakqkelsekqlsqataaatnhtt
dngvgpeeesvdpnqyykirsqaihqlkvngedpyphkfhvdisltdfiqkyshlqpgdh
ltditlkvagrihakrasggklifydlrgegvklqvmansrnykseeefihinnklrrgd
iigvqgnpgktkkgelsiipyeitllspclhmlphlhfglkdketryrqryldlilndfv
rqkfiirskiityirsfldelgfleietpmmniipggavakpfityhneldmnlymriap
elyhkmlvvggidrvyeigrqfrnegidlthnpefttcefymayadyhdlmeitekmvsg
mvkhitgsykvtyhpdgpegqaydvdftppfrrinmveelekalgmklpetnlfeteetr
kilddicvakavecppprttarlldklvgeflevtcinptficdhpqimsplakwhrske
glterfelfvmkkeicnaytelndpmrqrqlfeeqakakaagddeamfidenfctaleyg
lpptagwgmgidrvamfltdsnnikevllfpamkpedkkenvattdtlesttvgtsv

    Sequence, based on observed residues (ATOM records): (download) 
    >6chdB (B:)
svdpnqyykirsqaihqlkvngedpyphkfhvdisltdfiqkyshlqpgdhltditlkva
grihakrasggklifydlrgegvklqvmansrnykseeefihinnklrrgdiigvqgnpg
ktkkgelsiipyeitllspclhmlplkdketryrqryldlilndfvrqkfiirskiityi
rsfldelgfleietpmmniipggavakpfityhneldmnlymriapelyhkmlvvggidr
vyeigrqfrnegidlthnpefttcefymayadyhdlmeitekmvsgmvkhitgsykvtyh
pdgpegqaydvdftppfrrinmveelekalgmklpetnlfeteetrkilddicvakavec
ppprttarlldklvgeflevtcinptficdhpqimsplakwhrskeglterfelfvmkke
icnaytelndpmrqrqlfeeqakakaagddeamfidenfctaleyglpptagwgmgidrv
amfltdsnnikevllfpamkpe