PDB entry 6c99

View 6c99 on RCSB PDB site
Description: Crystal structure of FcRn bound to UCB-303
Class: immune system
Keywords: Neonatal Fc Receptor, FcRn, Inhibitor, beta 2 microglobulin, b2m, IMMUNE SYSTEM
Deposited on 2018-01-25, released 2018-05-30
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-05-30, with a file datestamp of 2018-05-25.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6c99a1, d6c99a2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6c99b_
  • Chain 'C':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6c99c1, d6c99c2
  • Chain 'D':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6c99d_
  • Heterogens: EQY, NAG, GOL, CIT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6c99A (A:)
    aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
    wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
    dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
    smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
    tvksgdehhyccivqhaglaqplrvelespakss
    

    Sequence, based on observed residues (ATOM records): (download)
    >6c99A (A:)
    hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywek
    ettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlk
    qgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmr
    lkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvk
    sgdehhyccivqhaglaqplrvele
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6c99B (B:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6c99C (C:)
    aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
    wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
    dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
    smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
    tvksgdehhyccivqhaglaqplrvelespakss
    

    Sequence, based on observed residues (ATOM records): (download)
    >6c99C (C:)
    hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywek
    ettdlrikeklfleafkalggkgpytlqgllgcelsvptakfalngeefmnfdlkqgtwg
    gdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmrlkarp
    sspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvksgdeh
    hyccivqhaglaqplrvele
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6c99D (D:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm