PDB entry 6bgt

View 6bgt on RCSB PDB site
Description: Structure of Trastuzumab Fab mutant in complex with Her2 extracellular domain
Class: transferase/immune system
Keywords: Herceptin, antibody, TRANSFERASE-IMMUNE SYSTEM complex
Deposited on 2017-10-29, released 2018-10-31
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-10-31, with a file datestamp of 2018-10-26.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Herceptin light chain mutant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BGT (0-103)
    • Uniprot Q7Z3Y4 (104-End)
    Domains in SCOPe 2.07: d6bgta1, d6bgta2
  • Chain 'B':
    Compound: Herceptin heavy chain Fab fragment mutant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BGT (0-108)
    • Uniprot P0DOX5 (109-End)
  • Chain 'C':
    Compound: Receptor tyrosine-protein kinase erbB-2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB2, HER2, MLN19, NEU, NGL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6bgtc1, d6bgtc2, d6bgtc3, d6bgtc4
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6bgtA (A:)
    diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysadflysgvps
    rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >6bgtA (A:)
    diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysadflysgvps
    rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnr
    

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6bgtC (C:)
    melaalcrwglllallppgaastqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnl
    eltylptnaslsflqdiqevqgyvliahnqvrqvplqrlrivrgtqlfednyalavldng
    dplnnttpvtgaspgglrelqlrslteilkggvliqrnpqlcyqdtilwkdifhknnqla
    ltlidtnrsrachpcspmckgsrcwgessedcqsltrtvcaggcarckgplptdccheqc
    aagctgpkhsdclaclhfnhsgicelhcpalvtyntdtfesmpnpegrytfgascvtacp
    ynylstdvgsctlvcplhnqevtaedgtqrcekcskpcarvcyglgmehlrevravtsan
    iqefagckkifgslaflpesfdgdpasntaplqpeqlqvfetleeitgylyisawpdslp
    dlsvfqnlqvirgrilhngaysltlqglgiswlglrslrelgsglalihhnthlcfvhtv
    pwdqlfrnphqallhtanrpedecvgeglachqlcarghcwgpgptqcvncsqflrgqec
    veecrvlqglpreyvnarhclpchpecqpqngsvtcfgpeadqcvacahykdppfcvarc
    psgvkpdlsympiwkfpdeegacqpcpincthscvdlddkgcpaeqrasplthhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >6bgtC (C:)
    tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
    yvliahnqvrqvplqrlrivrgtqlfednyalavldngdspgglrelqlrslteilkggv
    liqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgsrcwgessedcq
    sltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsgicelhcpalvt
    yntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqevtaedgtqrcek
    cskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfdgdpasntaplq
    peqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngaysltlqglgiswl
    glrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrpedecvgeglachq
    lcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpchpecqpqngs
    vtcfgpeadqcvacahykdppfcvarcpsympiwkfpdeegacqpcpin