PDB entry 6bgt

View 6bgt on RCSB PDB site
Description: Structure of Trastuzumab Fab mutant in complex with Her2 extracellular domain
Class: transferase/immune system
Keywords: Herceptin, antibody, TRANSFERASE-IMMUNE SYSTEM complex
Deposited on 2017-10-29, released 2018-10-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Herceptin light chain mutant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BGT (0-103)
    • Uniprot Q7Z3Y4 (104-End)
    Domains in SCOPe 2.08: d6bgta1, d6bgta2
  • Chain 'B':
    Compound: Herceptin heavy chain Fab fragment mutant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BGT (0-108)
    • Uniprot P0DOX5 (109-End)
    Domains in SCOPe 2.08: d6bgtb_
  • Chain 'C':
    Compound: Receptor tyrosine-protein kinase erbB-2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB2, HER2, MLN19, NEU, NGL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6bgtc1, d6bgtc2, d6bgtc3, d6bgtc4
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6bgtA (A:)
diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysadflysgvps
rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6bgtA (A:)
diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysadflysgvps
rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6bgtB (B:)
evqlvesggglvqpggslrlscaasgfniddtyihwvrqapgkglewvariyptngytry
adsvkgrftisadtskntaylqmnslraedtavyycsrwggdgfyamdywgqgtlvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6bgtB (B:)
evqlvesggglvqpggslrlscaasgfniddtyihwvrqapgkglewvariyptngytry
adsvkgrftisadtskntaylqmnslraedtavyycsrwggdgfyamdywgqgtlvtvss
astkgpsvfplaptaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssv
vtvpssslgtqtyicnvnhkpsntkvdkkv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6bgtC (C:)
melaalcrwglllallppgaastqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnl
eltylptnaslsflqdiqevqgyvliahnqvrqvplqrlrivrgtqlfednyalavldng
dplnnttpvtgaspgglrelqlrslteilkggvliqrnpqlcyqdtilwkdifhknnqla
ltlidtnrsrachpcspmckgsrcwgessedcqsltrtvcaggcarckgplptdccheqc
aagctgpkhsdclaclhfnhsgicelhcpalvtyntdtfesmpnpegrytfgascvtacp
ynylstdvgsctlvcplhnqevtaedgtqrcekcskpcarvcyglgmehlrevravtsan
iqefagckkifgslaflpesfdgdpasntaplqpeqlqvfetleeitgylyisawpdslp
dlsvfqnlqvirgrilhngaysltlqglgiswlglrslrelgsglalihhnthlcfvhtv
pwdqlfrnphqallhtanrpedecvgeglachqlcarghcwgpgptqcvncsqflrgqec
veecrvlqglpreyvnarhclpchpecqpqngsvtcfgpeadqcvacahykdppfcvarc
psgvkpdlsympiwkfpdeegacqpcpincthscvdlddkgcpaeqrasplthhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6bgtC (C:)
tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
yvliahnqvrqvplqrlrivrgtqlfednyalavldngdspgglrelqlrslteilkggv
liqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgsrcwgessedcq
sltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsgicelhcpalvt
yntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqevtaedgtqrcek
cskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfdgdpasntaplq
peqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngaysltlqglgiswl
glrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrpedecvgeglachq
lcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpchpecqpqngs
vtcfgpeadqcvacahykdppfcvarcpsympiwkfpdeegacqpcpin