PDB entry 6bft

View 6bft on RCSB PDB site
Description: Structure of Bevacizumab Fab mutant in complex with VEGF
Class: immune system
Keywords: Avastin, antibody, IMMUNE SYSTEM
Deposited on 2017-10-27, released 2018-10-31
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-10-31, with a file datestamp of 2018-10-26.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Avastin Heavy Chain Fab fragment mutant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFT (0-122)
    • Uniprot P0DOX5 (123-End)
  • Chain 'B':
    Compound: Avastin Light Chain Fab fragment mutant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFT (0-103)
    • Uniprot Q8TCD0 (104-213)
    Domains in SCOPe 2.07: d6bftb1, d6bftb2
  • Chain 'C':
    Compound: Vascular Endothelial Growth Factor A
    Species: Homo sapiens [TaxId:9606]
    Gene: VEGFA, VEGF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6bftc_
  • Chain 'G':
    Compound: Vascular Endothelial Growth Factor A
    Species: Homo sapiens [TaxId:9606]
    Gene: VEGFA, VEGF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6bftg_
  • Chain 'H':
    Compound: Avastin Heavy Chain Fab fragment mutant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFT (0-122)
    • Uniprot P0DOX5 (123-End)
  • Chain 'L':
    Compound: Avastin Light Chain Fab fragment mutant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFT (0-103)
    • Uniprot Q8TCD0 (104-End)
    Domains in SCOPe 2.07: d6bftl1, d6bftl2
  • Heterogens: SO4, MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6bftB (B:)
    diqmtqspsslsasvgdrvtitcsasqdisnylnwyqqkpgkapkvliyftddlhsgvps
    rfsgsgsgtdftltisslqpedfatyycqqystvpwtfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6bftC (C:)
    gpnhhevvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndegle
    cvpteesnitmqimrikphqgqhigemsflqhnkcecrpkkd
    

    Sequence, based on observed residues (ATOM records): (download)
    >6bftC (C:)
    vvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvptee
    snitmqimrikphqgqhigemsflqhnkcecrpk
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >6bftG (G:)
    gpnhhevvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndegle
    cvpteesnitmqimrikphqgqhigemsflqhnkcecrpkkd
    

    Sequence, based on observed residues (ATOM records): (download)
    >6bftG (G:)
    evvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvpte
    esnitmqimrikphqgqhigemsflqhnkcecrpk
    

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >6bftL (L:)
    diqmtqspsslsasvgdrvtitcsasqdisnylnwyqqkpgkapkvliyftddlhsgvps
    rfsgsgsgtdftltisslqpedfatyycqqystvpwtfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >6bftL (L:)
    diqmtqspsslsasvgdrvtitcsasqdisnylnwyqqkpgkapkvliyftddlhsgvps
    rfsgsgsgtdftltisslqpedfatyycqqystvpwtfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrge