PDB entry 6bfs

View 6bfs on RCSB PDB site
Description: The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies
Class: immune system
Keywords: Cytokine-Fab complex, Pulmonary Alveolar Proteinosis, receptor assembly, autoantibodies, IMMUNE SYSTEM
Deposited on 2017-10-26, released 2018-09-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-09-12, with a file datestamp of 2018-09-07.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: granulocyte-macrophage colony-stimulating factor
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF2, GMCSF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6bfsc1, d6bfsc2
  • Chain 'H':
    Compound: Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFS (0-216)
  • Chain 'L':
    Compound: Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFS (0-End)
    Domains in SCOPe 2.07: d6bfsl1, d6bfsl2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6bfsC (C:)
    aparspspstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrle
    lykqglrgsltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfd
    cwepvqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >6bfsC (C:)
    ehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrlelykqglrgsltkl
    kgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfdcwepv
    

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >6bfsL (L:)
    diqltqspsslsaslgdtititchasqninvwlswyqqkpgnipklliykasnlhtgvps
    rfsgsgsgtgftltisslqpediatyycqqgqsypltfgggtkleikradaaptvsifpp
    sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
    ltkdeyerhnsytceathktstspivksfnrnec
    

    Sequence, based on observed residues (ATOM records): (download)
    >6bfsL (L:)
    diqltqspsslsaslgdtititchasqninvwlswyqqkpgnipklliykasnlhtgvps
    rfsgsgsgtgftltisslqpediatyycqqgqsypltfgggtkleikradaaptvsifpp
    sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
    ltkdeyerhnsytceathktstspivksfnrn