PDB entry 6azv

View 6azv on RCSB PDB site
Description: IDO1/BMS-978587 crystal structure
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: IDO1 heme-displaced ligand-bound, oxidoreductase-oxidoreductase inhibitor complex
Deposited on 2017-09-13, released 2018-03-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-11, with a file datestamp of 2018-04-06.
Experiment type: XRAY
Resolution: 2.76 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Indoleamine 2,3-dioxygenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IDO1, IDO, INDO
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6azva_
  • Chain 'B':
    Compound: Indoleamine 2,3-dioxygenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IDO1, IDO, INDO
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6azvb_
  • Chain 'C':
    Compound: Indoleamine 2,3-dioxygenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IDO1, IDO, INDO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14902 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.08: d6azvc1, d6azvc2
  • Chain 'D':
    Compound: Indoleamine 2,3-dioxygenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IDO1, IDO, INDO
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6azvd_
  • Heterogens: C4V, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6azvA (A:)
gshmenswtiskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrervek
lnmlsidhltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelp
pilvyadcvlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikvi
ptvfkamqmqerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnp
qlsdglvyegfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrympp
ahrnflcslesnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqq
pkenktsedpskleakgtggtdlmnflktvrstteksllkeg

    Sequence, based on observed residues (ATOM records): (download) 
    >6azvA (A:)
tiskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidh
ltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadc
vlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamq
mqerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvy
egfwedpkefaggsagqssvfqcfdvllgiqqgghaaqflqdmrrymppahrnflcsles
npsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqdlmnflktvrst
teksllk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6azvB (B:)
gshmenswtiskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrervek
lnmlsidhltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelp
pilvyadcvlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikvi
ptvfkamqmqerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnp
qlsdglvyegfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrympp
ahrnflcslesnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqq
pkenktsedpskleakgtggtdlmnflktvrstteksllkeg

    Sequence, based on observed residues (ATOM records): (download) 
    >6azvB (B:)
tiskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidh
ltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadc
vlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamq
mqerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvy
egfwedpkefaggsagqssvfqcfdvllgiqqtghaaqflqdmrrymppahrnflcsles
npsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqdlmnflktvrst
teksllk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6azvC (C:)
gshmenswtiskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrervek
lnmlsidhltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelp
pilvyadcvlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikvi
ptvfkamqmqerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnp
qlsdglvyegfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrympp
ahrnflcslesnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqq
pkenktsedpskleakgtggtdlmnflktvrstteksllkeg

    Sequence, based on observed residues (ATOM records): (download) 
    >6azvC (C:)
hmenswtiskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrervekln
mlsidhltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppi
lvyadcvlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikvipt
vfkadtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvy
egfwedpkefaggsagqssvfqcfdvllgiqqhaaqflqdmrrymppahrnflcslesnp
svrefvlskglreaydacvkalvslrsyhlqivtkyilipasqdlmnflktvrstteksl
lk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6azvD (D:)
gshmenswtiskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrervek
lnmlsidhltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelp
pilvyadcvlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikvi
ptvfkamqmqerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnp
qlsdglvyegfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrympp
ahrnflcslesnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqq
pkenktsedpskleakgtggtdlmnflktvrstteksllkeg

    Sequence, based on observed residues (ATOM records): (download) 
    >6azvD (D:)
tiskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidh
ltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadc
vlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamq
mqerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvy
egfwedpkefaggsagqssvfqcfdvllgiqqthaaqflqdmrrymppahrnflcslesn
psvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqqtdlmnflktvrs
tteksl