PDB entry 6alc

View 6alc on RCSB PDB site
Description: CREBBP bromodomain in complex with Cpd 4 (1-(1-(cyclopropylmethyl)-3-(1H-indol-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Class: protein binding/inhibitor
Keywords: CREBBP, Bromodomain, small molecule inhibitor, PROTEIN BINDING-INHIBITOR complex
Deposited on 2017-08-07, released 2018-08-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-02-20, with a file datestamp of 2019-02-15.
Experiment type: XRAY
Resolution: 1.39 Å
R-factor: N/A
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: creb-binding protein
  Species: Homo sapiens [TaxId:9606]
  Gene: CREBBP, CBP
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q92793 (2-113)
    • expression tag (0-1)
    • conflict (112)
  Domains in SCOPe 2.08: d6alca1, d6alca2
• Chain 'B':
  Compound: creb-binding protein
  Species: Homo sapiens [TaxId:9606]
  Gene: CREBBP, CBP
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q92793 (2-113)
    • expression tag (0-1)
    • conflict (112)
  Domains in SCOPe 2.08: d6alcb1, d6alcb2
• Heterogens: DMS, EDO, BKD, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6alcA (A:)
  aafkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivknpmdlstikrkl
  dtgqyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqal
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6alcB (B:)
  aafkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivknpmdlstikrkl
  dtgqyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqal