PDB entry 6a3c

View 6a3c on RCSB PDB site
Description: MVM NES mutant Nm12 in complex with CRM1-Ran-RanBP1
Class: transport protein
Keywords: transport protein, nuclear export, complex, mutant, inhibitor
Deposited on 2018-06-15, released 2019-06-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-16, with a file datestamp of 2021-06-11.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Gene: RAN, ARA24, OK/SW-cl.81
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62826 (Start-234)
      • engineered mutation (215)
    Domains in SCOPe 2.08: d6a3ca_
  • Chain 'B':
    Compound: Ran-specific GTPase-activating protein 1
    Species: Saccharomyces cerevisiae [TaxId:559292]
    Gene: YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6a3cb_
  • Chain 'C':
    Compound: Exportin-1
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: CRM1, KAP124, XPO1, YGR218W, G8514
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30822 (3-End)
      • expression tag (1-2)
      • engineered mutation (481)
      • engineered mutation (483-485)
      • engineered mutation (966)
  • Chain 'D':
    Compound: MVM NES mutant Nm12
    Species: Minute virus of mice [TaxId:10794]
    Gene: NS2
    Database cross-references and differences (RAF-indexed):
    • PDB 6A3C
  • Heterogens: GTP, MG, EDO, GOL, CL, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6a3cA (A:)
gsshhhhhhssglvprgshmaaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyva
tlgvevhplvfhtnrgpikfnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknv
pnwhrdlvrvcenipivlcgnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpf
lwlarkligdpnlefvampalappevvmdpalaaqaehdlevaqttalpdedddl

    Sequence, based on observed residues (ATOM records): (download) 
    >6a3cA (A:)
pqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdt
agqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdi
kdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappe
vvmdpalaaqaehdlevaqttalpdedddl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6a3cB (B:)
ggsdihfepvvhlekvdvktmeedeevlykvraklfrfdadakewkergtgdckflknkk
tnkvrilmrrdktlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairf
gskenadkfkeefekaqeinkka

    Sequence, based on observed residues (ATOM records): (download) 
    >6a3cB (B:)
hfepvtmeedeevlykvraklfrfdadakewkergtgdckflknkktnkvrilmrrdktl
kicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgskenadkfkeefe
kaqeinkk

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.