PDB entry 5zfa

View 5zfa on RCSB PDB site
Description: Structure of human dihydroorotate dehydrogenase in complex with 287-12-OCOiPr
Class: oxidoreductase
Keywords: rossmann fold, dihydroorotate/orotate, ubiquinone/ubiquinol, mitochondrial inner membrane, inhibitor complex, oxidoreductase
Deposited on 2018-03-02, released 2018-09-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-09-26, with a file datestamp of 2018-09-21.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5zfaa_
  • Heterogens: FMN, ORO, ACT, SO4, 9BU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5zfaA (A:)
    mghhhhhhhhhhssghiddddkhmatgderfyaehlmptlqglldpesahrlavrftslg
    llprarfqdsdmlevrvlghkfrnpvgiaagfdkhgeavdglykmgfgfveigsvtpkpq
    egnprprvfrlpedqavinrygfnshglsvvehrlrarqqkqakltedglplgvnlgknk
    tsvdaaedyaegvrvlgpladylvvnvsspntaglrslqgkaelrrlltkvlqerdglrr
    vhrpavlvkiapdltsqdkediasvvkelgidglivtnttvsrpaglqgalrsetgglsg
    kplrdlstqtiremyaltqgrvpiigvggvssgqdalekiragaslvqlytaltfwgppv
    vgkvkreleallkeqgfggvtdaigadhrr
    

    Sequence, based on observed residues (ATOM records): (download)
    >5zfaA (A:)
    atgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrn
    pvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfn
    shglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylv
    vnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedias
    vvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpi
    igvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdai
    gadhrr