PDB entry 5yxu

View 5yxu on RCSB PDB site
Description: an affinity enhanced T cell receptor in complex with HLA-A0201 restricted HCV NS3 peptide KLVALGINAV
Class: immune system
Keywords: affinity enhanced TCR-pHLA complex, IMMUNE SYSTEM
Deposited on 2017-12-07, released 2018-12-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-12-12, with a file datestamp of 2018-12-07.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: T cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5YXU (0-190)
    Domains in SCOPe 2.07: d5yxua1, d5yxua2
  • Chain 'B':
    Compound: T cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5YXU (0-241)
    Domains in SCOPe 2.07: d5yxub1, d5yxub2
  • Chain 'C':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5yxuc1, d5yxuc2
  • Chain 'D':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5YXU (0-99)
    Domains in SCOPe 2.07: d5yxud_
  • Chain 'E':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01892 (0-274)
      • expression tag (275)
    Domains in SCOPe 2.07: d5yxue1, d5yxue2, d5yxue3
  • Chain 'F':
    Compound: T cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5YXU (Start-190)
    Domains in SCOPe 2.07: d5yxuf1, d5yxuf2
  • Chain 'G':
    Compound: T cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5YXU
    Domains in SCOPe 2.07: d5yxug1, d5yxug2
  • Chain 'H':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5YXU (Start-99)
    Domains in SCOPe 2.07: d5yxuh_
  • Chain 'I':
    Compound: lys-leu-val-ala-leu-gly-ile-asn-ala-val
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • PDB 5YXU (0-9)
  • Chain 'J':
    Compound: lys-leu-val-ala-leu-gly-ile-asn-ala-val
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • PDB 5YXU (0-9)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5yxuA (A:)
    aqtvtqsqpemsvqeaetvtlsctydtsendyilfwykqppsrqmilvirqeaykqqnat
    enrfsvnfqkaaksfslkisdsqlgdaamyfcaygeddkiifgkgtrlhilpniqnpdpa
    vyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnk
    sdfacanafnn
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5yxuB (B:)
    aeadiyqtprylvigtgkkitlecsqtmghdkmywyqqdpgmelhlihysygvnstekgd
    lssestvsrirtehfpltlesarpshtsqylcasrrgsaelyfgpgtrltvtedlknvfp
    pevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpa
    lndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgr
    aa
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5yxuC (C:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwea
    

    Sequence, based on observed residues (ATOM records): (download)
    >5yxuC (C:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5yxuD (D:)
    giqrtpkiqvysrhpaengksnflncyvsgfhpseievdllkngeriekvehsdlsfsed
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5yxuE (E:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwea
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >5yxuF (F:)
    aqtvtqsqpemsvqeaetvtlsctydtsendyilfwykqppsrqmilvirqeaykqqnat
    enrfsvnfqkaaksfslkisdsqlgdaamyfcaygeddkiifgkgtrlhilpniqnpdpa
    vyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnk
    sdfacanafnn
    

    Sequence, based on observed residues (ATOM records): (download)
    >5yxuF (F:)
    qtvtqsqpemsvqeaetvtlsctydtsendyilfwykqppsrqmilvirqeaykqqnate
    nrfsvnfqkaaksfslkisdsqlgdaamyfcaygeddkiifgkgtrlhilpniqnpdpav
    yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnks
    dfacanafnn
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >5yxuG (G:)
    aeadiyqtprylvigtgkkitlecsqtmghdkmywyqqdpgmelhlihysygvnstekgd
    lssestvsrirtehfpltlesarpshtsqylcasrrgsaelyfgpgtrltvtedlknvfp
    pevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpa
    lndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgr
    aa
    

    Sequence, based on observed residues (ATOM records): (download)
    >5yxuG (G:)
    adiyqtprylvigtgkkitlecsqtmghdkmywyqqdpgmelhlihysygvnstekgdls
    sestvsrirtehfpltlesarpshtsqylcasrrgsaelyfgpgtrltvtedlknvfppe
    vavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpaln
    dsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >5yxuH (H:)
    giqrtpkiqvysrhpaengksnflncyvsgfhpseievdllkngeriekvehsdlsfsed
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

    Sequence, based on observed residues (ATOM records): (download)
    >5yxuH (H:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpseievdllkngeriekvehsdlsfsedw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.