PDB entry 5xsr

View 5xsr on RCSB PDB site
Description: novel orally efficacious inhibitors complexed with PARP1
Class: transferase/transferase inhibitor
Keywords: complex structure, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2017-06-15, released 2018-04-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-04-25, with a file datestamp of 2018-04-20.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Poly [ADP-ribose] polymerase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP1, ADPRT, PPOL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09874 (5-End)
      • variant (105)
    Domains in SCOPe 2.07: d5xsra1, d5xsra2
  • Heterogens: 8EC, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5xsrA (A:)
    gplgsksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsev
    qqavsqgssdsqildlsnrfytliphdfgmkkppllnnadsvqakaemldnlldievays
    llrggsddsskdpidvnyeklktdikvvdrdseeaeiirkyvknthatthnaydlevidi
    fkieregecqrykpfkqlhnrrllwhgsrttnfagilsqglriappeapvtgymfgkgiy
    fadmvsksanychtsqgdpiglillgevalgnmyelkhashisklpkgkhsvkglgkttp
    dpsanisldgvdvplgtgissgvndtsllyneyivydiaqvnlkyllklkfnfkt
    

    Sequence, based on observed residues (ATOM records): (download)
    >5xsrA (A:)
    ksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavs
    qgssdsqildlsnrfytliphdfgmkkppllnnadsvqakaemldnlldievaysllrgg
    ssskdpidvnyeklktdikvvdrdseeaeiirkyvknthaaydlevidifkieregecqr
    ykpfkqlhnrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfadmvsksany
    chtsqgdpiglillgevalgnmyelkhashisklpkgkhsvkglgkttpdpsanisldgv
    dvplgtgissgvndtsllyneyivydiaqvnlkyllklkfnfk