PDB entry 5whk

View 5whk on RCSB PDB site
Description: Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M
Class: immune system
Keywords: neonatal receptor, Fc, antibody recycling, IMMUNE SYSTEM
Deposited on 2017-07-17, released 2017-09-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-06, with a file datestamp of 2017-09-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5whka1, d5whka2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5whkb_
  • Chain 'H':
    Compound: DX-2507 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5WHK (0-104)
    • Uniprot S6BAN1 (105-End)
  • Chain 'L':
    Compound: DX-2507 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5WHK (0-97)
    • Uniprot Q6NS95 (98-End)
    Domains in SCOPe 2.07: d5whkl1, d5whkl2
  • Heterogens: EDO, NHE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5whkA (A:)
    mgvprpqpwalglllfllpgslgaeshlsllyhltavsspapgtpafwvsgwlgpqqyls
    ynslrgeaepcgawvwenqvswywekettdlrikeklfleafkalggkgpytlqgllgce
    lgpdntsvptakfalngeefmnfdlkqgtwggdwpealaisqrwqqqdkaankeltfllf
    scphrlrehlergrgnlewkeppsmrlkarpsspgfsvltcsafsfyppelqlrflrngl
    aagtgqgdfgpnsdgsfhasssltvksgdehhyccivqhaglaqplrvelespakss
    

    Sequence, based on observed residues (ATOM records): (download)
    >5whkA (A:)
    hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvswywekettdl
    rikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlkqgtwg
    gdwpealaisqrwqqqdkaankeltfllfscphrlrehlwkeppsmrlkarpsspgfsvl
    tcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvksgdehhyccivqh
    aglaqplrvelesp
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5whkB (B:)
    msrsvalavlallslsgleaiqrtpkiqvysrhpaengksnflncyvsgfhpsdievdll
    kngeriekvehsdlsfskdwsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

    Sequence, based on observed residues (ATOM records): (download)
    >5whkB (B:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >5whkL (L:)
    qsaltqpasvsgspgqsitisctgtgsdvgsynlvswyqqhpgkapklmiygdsqrpsgv
    snrfsgsksgntasltisglqaedeadyycasyagsgiyvfgtgtkvtvlgqpkanptvt
    lfppsseelqankatlvclisdfypgavtvawkadgspvkagvettkpskqsnnkyaass
    ylsltpeqwkshrsyscqvthegstvektvaptecs
    

    Sequence, based on observed residues (ATOM records): (download)
    >5whkL (L:)
    qsaltqpasvsgspgqsitisctgtgsdvgsynlvswyqqhpgkapklmiygdsqrpsgv
    snrfsgsksgntasltisglqaedeadyycasyagsgiyvfgtgtkvtvlgqpkanptvt
    lfppsseelqankatlvclisdfypgavtvawkadgspvkagvettkpskqsnnkyaass
    ylsltpeqwkshrsyscqvthegstvektvap