PDB entry 5wgl

View 5wgl on RCSB PDB site
Description: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with ricolinostat (ACY-1215)
Class: hydrolase/hydrolase inhibitor
Keywords: histone deacetylase, hydrolase inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2017-07-14, released 2017-12-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-03, with a file datestamp of 2017-12-29.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hdac6 protein
    Species: Danio rerio [TaxId:7955]
    Gene: HDAC6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5wgla_
  • Chain 'B':
    Compound: Hdac6 protein
    Species: Danio rerio [TaxId:7955]
    Gene: HDAC6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5wglb_
  • Heterogens: ZN, K, AH4, EDO, PEG, FLC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5wglA (A:)
snaggsspitglvydqrmmlhhnmwdshhpelpqrisrifsrheelrllsrchriparla
teeelalchsskhisiikssehmkprdlnrlgdeynsifisnesytcallaagscfnsaq
ailtgqvrnavaivrppghhaekdtacgfcffntaaltaryaqsitreslrvlivdwdvh
hgngtqhifeeddsvlyislhryedgaffpnsedanydkvglgkgrgynvnipwnggkmg
dpeymaafhhlvmpiarefapelvlvsagfdaargdplggfqvtpegyahlthqlmslaa
grvliileggynltsisesmsmctsmllgdsppsldhltplktsatvsinnvlrahapfw
sslr

    Sequence, based on observed residues (ATOM records): (download) 
    >5wglA (A:)
spitglvydqrmmlhhnmwdshhpelpqrisrifsrheelrllsrchriparlateeela
lchsskhisiikssehmkprdlnrlgdeynsifisnesytcallaagscfnsaqailtgq
vrnavaivrppghhaekdtacgfcffntaaltaryaqsitreslrvlivdwdvhhgngtq
hifeeddsvlyislhryedgaffpnsedanydkvglgkgrgynvnipwnggkmgdpeyma
afhhlvmpiarefapelvlvsagfdaargdplggfqvtpegyahlthqlmslaagrvlii
leggynltsisesmsmctsmllgdsppsldhltplktsatvsinnvlrahapfwsslr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5wglB (B:)
snaggsspitglvydqrmmlhhnmwdshhpelpqrisrifsrheelrllsrchriparla
teeelalchsskhisiikssehmkprdlnrlgdeynsifisnesytcallaagscfnsaq
ailtgqvrnavaivrppghhaekdtacgfcffntaaltaryaqsitreslrvlivdwdvh
hgngtqhifeeddsvlyislhryedgaffpnsedanydkvglgkgrgynvnipwnggkmg
dpeymaafhhlvmpiarefapelvlvsagfdaargdplggfqvtpegyahlthqlmslaa
grvliileggynltsisesmsmctsmllgdsppsldhltplktsatvsinnvlrahapfw
sslr

    Sequence, based on observed residues (ATOM records): (download) 
    >5wglB (B:)
itglvydqrmmlhhnmwdshhpelpqrisrifsrheelrllsrchriparlateeelalc
hsskhisiikssehmkprdlnrlgdeynsifisnesytcallaagscfnsaqailtgqvr
navaivrppghhaekdtacgfcffntaaltaryaqsitreslrvlivdwdvhhgngtqhi
feeddsvlyislhryedgaffpnsedanydkvglgkgrgynvnipwnggkmgdpeymaaf
hhlvmpiarefapelvlvsagfdaargdplggfqvtpegyahlthqlmslaagrvliile
ggynltsisesmsmctsmllgdsppsldhltplktsatvsinnvlrahapfwsslr