PDB entry 5w8t

View 5w8t on RCSB PDB site
Description: Crystal structure of MERS-CoV papain-like protease in complex with the C-terminal domain of human ISG15
Class: signaling protein
Keywords: Signaling protein, Hydrolase, papain-like protease, ISG15
Deposited on 2017-06-22, released 2017-09-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 2.76 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ORF1ab protein
    Species: Human betacoronavirus 2c Jordan-N3/2012 [TaxId:1306931]
    Gene: orf1ab
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5w8ta1, d5w8ta2
  • Chain 'B':
    Compound: Ubiquitin-like protein ISG15
    Species: Homo sapiens [TaxId:9606]
    Gene: ISG15, G1P2, UCRP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5w8tb_
  • Chain 'C':
    Compound: ORF1ab protein
    Species: Human betacoronavirus 2c Jordan-N3/2012 [TaxId:1306931]
    Gene: orf1ab
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5w8tc1, d5w8tc2
  • Chain 'D':
    Compound: Ubiquitin-like protein ISG15
    Species: Homo sapiens [TaxId:9606]
    Gene: ISG15, G1P2, UCRP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5w8td_
  • Heterogens: AYE, ZN, MPD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5w8tA (A:)
qltievlvtvdgvnfrtvvlnnkntyrsqlgcvffngadisdtipdekqnghslyladnl
tadetkalkelygpvdptflhrfyslkaavhgwkmvvcdkvrslklsdnncylnavimtl
dllkdikfvipalqhafmkhkggdstdfialimaygnctfgapddasrllhtvlakaelc
csarmvwrewcnvcgikdvvlqglkaccyvgvqtvedlrarmtyvcqcggerhrqlveht
tpwlllsgtpneklvttstapdfvafnvfqgietavghyvharlkgglilkfdsgtvskt
sdwkckvtdvlfpgqkyssdcn

    Sequence, based on observed residues (ATOM records): (download) 
    >5w8tA (A:)
ltievlvtvdgvnfrtvvlnnkntyrsqlgcvffngadisdtipdekqnghslyladnlt
adetkalkelygpvdptflhrfyslkaavhgwkmvvcdkvrslklsdnncylnavimtld
llkdikfvipalqhafmkhkggdstdfialimaygnctfgapddasrllhtvlakaelcc
sarmvwrewcnvcgikdvvlqglkaccyvgvqtvedlrarmtyvcqcggerhrqlvehtt
pwlllsgtpneklvttstapdfvafnvfqgietavghyvharlkgglilkfdsgtvskts
dwkckvtdvlfpgqkyssd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5w8tB (B:)
meplsilvrnnkgrsstyevrltqtvahlkqqvsglegvqddlfwltfegkpledqlplg
eyglkplstvfmnlrlrgx

    Sequence, based on observed residues (ATOM records): (download) 
    >5w8tB (B:)
eplsilvrnnkgrsstyevrltqtvahlkqqvsglegvqddlfwltfegkpledqlplge
yglkplstvfmnlrlrg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5w8tC (C:)
qltievlvtvdgvnfrtvvlnnkntyrsqlgcvffngadisdtipdekqnghslyladnl
tadetkalkelygpvdptflhrfyslkaavhgwkmvvcdkvrslklsdnncylnavimtl
dllkdikfvipalqhafmkhkggdstdfialimaygnctfgapddasrllhtvlakaelc
csarmvwrewcnvcgikdvvlqglkaccyvgvqtvedlrarmtyvcqcggerhrqlveht
tpwlllsgtpneklvttstapdfvafnvfqgietavghyvharlkgglilkfdsgtvskt
sdwkckvtdvlfpgqkyssdcn

    Sequence, based on observed residues (ATOM records): (download) 
    >5w8tC (C:)
ltievlvtvdgvnfrtvvlnnkntyrsqlgcvffngadisdtipdekqnghslyladnlt
adetkalkelygpvdptflhrfyslkaavhgwkmvvcdkvrslklsdnncylnavimtld
llkdikfvipalqhafmkhkggdstdfialimaygnctfgapddasrllhtvlakaelcc
sarmvwrewcnvcgikdvvlqglkaccyvgvqtvedlrarmtyvcqcggerhrqlvehtt
pwlllsgtpneklvttstapdfvafnvfqgietavghyvharlkgglilkfdsgtvskts
dwkckvtdvlfpgqkyssd

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5w8tD (D:)
meplsilvrnnkgrsstyevrltqtvahlkqqvsglegvqddlfwltfegkpledqlplg
eyglkplstvfmnlrlrgx

    Sequence, based on observed residues (ATOM records): (download) 
    >5w8tD (D:)
eplsilvrnnkgrsstyevrltqtvahlkqqvsglegvqddlfwltfegkpledqlplge
yglkplstvfmnlrlrg